Ace 250 mg

Description

Indications

Ace is an effective solution for reducing fever and relieving mild to moderate pain associated with:

• Common cold, flu, and fever
• Headache, toothache, earache, and body ache
• Muscle pain (myalgia), neuralgia, and dysmenorrhea
• Sprains, colic pain, back pain, and post-operative pain
• Postpartum discomfort and vaccination-related pain in children
• Rheumatic and osteoarthritic pain, easing joint stiffness

Use under the guidance of a registered physician.

Pharmacology

Ace contains Paracetamol (Acetaminophen), a well-researched analgesic and antipyretic. It works by:

• Blocking pain signals through inhibition of cyclooxygenase (COX) enzymes in the central nervous system.
• Reducing fever by acting on the hypothalamic heat-regulating center, promoting vasodilation and sweating.
• Unlike NSAIDs, Ace does not cause gastric irritation or affect blood clotting, making it a safer choice for pain relief.

Dosage & Administration

Tablet Form:

• Adults: 1-2 tablets every 4-6 hours (max 8 tablets/day)
• Children (6-12 years): ½ -1 tablet 3-4 times daily

Extended-Release Tablet:

• Adults & Children (12+ years): 2 tablets every 6-8 hours (max 6 tablets/day)

Syrup/Suspension:

• Infants (Under 3 months): 10 mg/kg (reduce to 5 mg/kg if jaundiced)
• 1-5 years: 1-2 teaspoons 3-4 times daily
• Adults: 4-8 teaspoons 3-4 times daily

Suppository:

• Children (3 months – 12 years): 60-500 mg (based on age) up to 4 times daily
• Adults: 0.5-1g up to 4 times daily

Paediatric Drops:

• Up to 3 months: 0.5 ml (40 mg)
• 4 to 11 months: 1.0 ml (80 mg)
• 1-2 years: 1.5 ml (120 mg) (Max: 5 doses/day, up to 5 days)

IV Infusion:

• Adults & Adolescents (50kg+): 1000 mg every 6 hours or 650 mg every 4 hours (Max: 4000 mg/day)
• Children (2-12 years): 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours (Max: 75 mg/kg/day)

Do not exceed the recommended dosage.

Drug Interactions

• Alcohol, barbiturates, and certain antidepressants may increase the risk of liver toxicity.
• Chronic use of anticonvulsants or steroid contraceptives may lower the effectiveness of Ace.

Contraindications

• Not suitable for individuals with known hypersensitivity to Paracetamol.

Possible Side Effects

Though generally well-tolerated, rare side effects may include:

• Blood disorders like thrombocytopenia and neutropenia
• Skin reactions and allergic responses
• Rare cases of pancreatitis

Use in Pregnancy & Lactation

• Safe within recommended doses during pregnancy.
• Small amounts may pass into breast milk but are not considered harmful.

Precautions & Warnings

• Use with caution in patients with liver or kidney disease.
• Avoid exceeding the stated dose, especially in those with alcoholism or malnutrition.
• Discontinue immediately if allergic reactions occur.

Overdose Management

• Overdosing can cause liver damage, nausea, vomiting, and, in severe cases, hepatic failure.
• Early treatment with activated charcoal (within 1 hour) and N-acetylcysteine (within 8 hours) is critical for preventing toxicity.

Storage Guidelines

• Store in a cool, dry place away from heat and sunlight.
• Keep out of reach of children.

Therapeutic Class

• Non-opioid Analgesic & Antipyretic

Molecular Formula: C₈H₉NO₂