Ace Plus 500 mg+65 mg

Description

Indications
Ace Plus is used to relieve various types of pain and fever, including:

• Headache
• Migraine
• Toothache
• Neuralgia
• Fever
• Menstrual pain
• Sore throat
• Back pain
• Reduction of high body temperature
• Aches and pains associated with colds and flu

Take this medication as per the advice of a registered physician.

Pharmacology
Ace Plus is a combination of Paracetamol and Caffeine. Paracetamol acts as an analgesic (pain reliever) and antipyretic (fever reducer) with mild anti-inflammatory properties. Caffeine, a xanthine derivative similar to theophylline, enhances the effectiveness of Paracetamol by increasing its solubility and ability to pass through cell membranes. Additionally, Caffeine helps to raise the pain threshold, improving pain tolerance. It also has a vasoconstrictive effect on blood vessels in the brain, which can be beneficial for treating migraines and headaches.

Dosage & Administration

• Adults: 1-2 tablets every 4-6 hours as needed. Maximum of 8 tablets per day.
• Children: Not recommended for children under 12 years of age.

Take this medication as per the advice of a registered physician.

Drug Interactions

• May decrease blood levels when used with anticonvulsants such as phenytoin, barbiturates, and carbamazepine.
• Long-term use may enhance the blood-thinning effects of warfarin and other coumarins.
• May lead to faster absorption when taken with metoclopramide and domperidone.
• Serum levels may increase when combined with probenecid or chloramphenicol.
• May reduce absorption if taken within an hour of colestyramine.
• Severe hypothermia may occur when combined with phenothiazines.

Contraindications
Ace Plus should not be used in individuals with:

• Severe kidney impairment
• Liver disease, including viral hepatitis
• Known allergy to Paracetamol or Caffeine

Side Effects
Paracetamol is generally well tolerated, but possible side effects include:

• Blood disorders such as thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis
• Rare cases of pancreatitis
• Skin rashes and other allergic reactions

Use in Pregnancy & Lactation

• Pregnant women should consult a doctor before using this medication.
• Paracetamol & Caffeine can be taken while breastfeeding.

Precautions & Warnings

• Use with caution in individuals with liver or kidney disease.
• Avoid prolonged use without medical supervision.
• Patients taking other medications that may affect the liver should consult a doctor before use.

Overdose Effects
Symptoms of overdose within the first 24 hours include:

• Pallor (pale skin)
• Nausea and vomiting
• Loss of appetite
• Abdominal pain

Liver damage may become evident within 12 to 48 hours. Other possible complications include metabolic acidosis and disturbances in glucose metabolism.

Therapeutic Class
Non-opioid analgesics

Storage Conditions

• Store in a cool, dry place, away from direct light and moisture.
• Keep out of reach of children.