Acerux 3%

Description

Indications
Acerux is indicated for the treatment of Herpes simplex keratitis.

Pharmacology
Acyclovir is an antiviral agent that is highly active against Herpes simplex virus (HSV) types I and II, as well as Varicella zoster virus, with low toxicity to mammalian cells. Once inside herpes-infected cells, Acyclovir is phosphorylated to Acyclovir triphosphate by viral-coded thymidine kinase. This active form inhibits herpes-specific DNA polymerase, preventing further viral DNA synthesis without disrupting normal cellular processes.

Dosage & Administration
The same dosage applies to all age groups. Apply a 10 mm ribbon of the ointment into the lower conjunctival sac five times a day at approximately 4-hour intervals. Continue treatment for at least 3 days after healing.

Interaction
No clinically significant interactions have been identified.

Contraindications
Acyclovir is contraindicated in patients with known hypersensitivity to Acyclovir or Valacyclovir.

Side Effects

• Very common: Superficial punctate keratopathy (heals without sequelae and does not require early therapy termination).
• Common: Mild transient stinging immediately after application, conjunctivitis.
• Rare: Blepharitis.

Pregnancy & Lactation

• Pregnancy: Category B. There are no adequate, well-controlled studies of Acyclovir in pregnant women.
• Lactation: It is unknown if topically applied Acyclovir is excreted in breast milk.

Precautions & Warnings
Do not exceed the recommended dosage, frequency, or duration of treatment.

Overdose Effects
No adverse effects are expected if the entire contents of the tube (90 mg Acyclovir) are ingested orally.

Therapeutic Class
Ophthalmic Anti-viral Products

Storage Conditions
Store in a cool, dry place, away from light. Keep out of reach of children. Avoid touching the tube’s tip to prevent contamination. Do not use the ointment more than one month after opening.