Acyvir 3%

Description

Indications
Acyvir is indicated for the treatment of Herpes simplex keratitis.

Pharmacology
Acyclovir is a potent antiviral agent effective against Herpes simplex virus (HSV) types I and II and Varicella zoster virus, with low toxicity to mammalian cells. After entering herpes-infected cells, Acyclovir is phosphorylated to Acyclovir triphosphate by viral-coded thymidine kinase. This active form inhibits herpes-specific DNA polymerase, preventing viral DNA synthesis without disrupting normal cellular functions.

Dosage & Administration
Apply a 10 mm ribbon of the ointment into the lower conjunctival sac five times daily at 4-hour intervals. Continue treatment for at least 3 days after healing.

Interaction
No clinically significant drug interactions have been identified.

Contraindications
Contraindicated in patients with known hypersensitivity to Acyclovir or Valacyclovir.

Side Effects

• Very common: Superficial punctate keratopathy (heals without sequelae).
• Common: Mild transient stinging after application, conjunctivitis.
• Rare: Blepharitis.

Pregnancy & Lactation

• Pregnancy: Category B. There are no adequate, well-controlled studies of Acyclovir use in pregnant women.
• Lactation: It is unknown if topically applied Acyclovir is excreted in breast milk.

Precautions & Warnings
Do not exceed the recommended dosage, frequency, or treatment duration.

Overdose Effects
No adverse effects are expected if the entire contents of a 90 mg Acyvir tube are ingested orally.

Therapeutic Class
Ophthalmic Anti-viral Products

Storage Conditions
Store in a cool, dry place, away from light. Keep out of reach of children. Avoid contact with the tube tip to prevent contamination. Do not use the ointment more than one month after opening.