Adlina 5 mg

Description

Indications

Adlina is prescribed for adults with type 2 diabetes mellitus to help regulate blood sugar levels.

• As monotherapy: Recommended for patients whose blood sugar levels are not adequately controlled through diet and exercise alone and for whom metformin is unsuitable due to intolerance or contraindications related to kidney impairment.

Pharmacology

Linagliptin, the active ingredient in Adlina, is a dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme plays a role in breaking down incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). By inhibiting DPP-4, Linagliptin increases the levels of these active incretin hormones, leading to enhanced insulin release from pancreatic beta (β) cells in a glucose-dependent manner while reducing glucagon secretion from pancreatic alpha (α) cells. This process helps to maintain blood sugar levels within a controlled range.

Dosage & Administration

• The recommended dose of Linagliptin is 5 mg once daily.
• When used with metformin, the metformin dosage should remain unchanged, and Linagliptin should be taken alongside it.
• If combined with a sulfonylurea, a lower dose of the sulfonylurea may be considered to minimize the risk of hypoglycemia.
• Patients with renal impairment: No dose adjustment is required.
• Adlina can be taken with or without food at any time of the day.

Drug Interactions

• Adlina is a weak to moderate inhibitor of the CYP3A4 enzyme but does not significantly affect other CYP enzymes.
• Clinical studies have shown that Adlina does not have any significant impact on the pharmacokinetics of commonly used medications such as metformin, glyburide, simvastatin, warfarin, digoxin, or oral contraceptives.

Contraindications

• Patients with a known hypersensitivity to Linagliptin or any of the excipients in the formulation should not take this medication.

Side Effects

Common side effects may include:

• Hypoglycemia (especially when used in combination with metformin and sulfonylurea)
• Nasopharyngitis (common cold)
• Cough
• Pancreatitis (rare but serious)

Pregnancy & Lactation

• Pregnancy Category B: There are no well-controlled studies on the use of Linagliptin in pregnant women. It should only be used during pregnancy if clearly necessary.
• It is unknown whether Linagliptin is excreted in breast milk; therefore, caution is advised when prescribing to breastfeeding mothers.

Precautions & Warnings

• Patients with a history of hypersensitivity to Linagliptin or any excipients should avoid this medication.
• Regular monitoring of blood sugar levels is recommended to ensure optimal glycemic control.

Therapeutic Class

• Dipeptidyl Peptidase-4 (DPP-4) Inhibitors

Storage Conditions

• Store in a dry place, away from light and heat.
• Keep out of reach of children.

Chemical Composition

• Molecular Formula: C₂₅H₂₈N₈O₂

Frequently Asked Questions (FAQs)

What is Adlina 5 mg Tablet?
Adlina 5 mg Tablet is a DPP-4 inhibitor used to control blood sugar levels in adults with type 2 diabetes mellitus.

How long does it take to see results with Adlina 5 mg Tablet?
The duration of treatment depends on individual response. Continue taking it as prescribed by your doctor for optimal results.

How should I take Adlina 5 mg Tablet?
Follow your doctor’s instructions regarding dosage. It can be taken with or without food.

Does Adlina 5 mg Tablet need to be taken at a specific time?
It should be taken at the same time each day to maintain consistent blood levels.

What are the storage and disposal instructions for Adlina 5 mg Tablet?
Store in a cool, dry place, away from direct sunlight. Ensure it is kept out of reach of children and pets.

Quick Tips

• Take Adlina 5 mg Tablet at the same time each day to avoid missing doses.
• When combined with other diabetes medications, there may be a risk of hypoglycemia. Keep a source of sugar or juice nearby in case of symptoms such as cold sweats, pale skin, shaking, or anxiety.
• Be cautious while driving or operating machinery until you understand how this medication affects you.
• Inform your doctor if you experience joint pain or symptoms such as stomach pain, nausea, or vomiting.