AERON 10 mg

Description

Indications Aeron is prescribed for:

• Preventing and managing chronic asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Alleviating symptoms of Allergic Rhinitis (AR), including both Seasonal and Perennial Allergic Rhinitis

Take this medication as advised by a registered physician.

Pharmacology Montelukast, the active ingredient in Aeron, is a selective leukotriene receptor antagonist that works by inhibiting the cysteinyl leukotriene receptor (CysLT1). Cysteinyl leukotrienes (LTC4, LTD4, LTE4) originate from arachidonic acid metabolism and are released by various cells, such as mast cells and eosinophils. These leukotrienes contribute to asthma and allergic rhinitis by causing airway swelling, smooth muscle constriction, and other inflammatory responses, which lead to asthma symptoms.

Dosage & Administration

• Adults and adolescents (15 years and older) with asthma or seasonal allergic rhinitis: 10 mg Montelukast tablet once daily.
• Pediatric patients with asthma or seasonal allergic rhinitis:
  • 6 to 14 years: 5 mg tablet once daily.
  • 2 to 5 years: 4 mg tablet once daily.
  • 6 months to 5 years: 4 mg oral granules once daily. These can be taken directly or mixed with cold water or soft food at room temperature.
• Use in pediatric patients: The safety and effectiveness of Montelukast have been confirmed in well-controlled studies for children aged 6 months to 14 years, with similar efficacy profiles to adults.
• Hepatic Insufficiency: No dosage adjustment is required for mild-to-moderate hepatic impairment.
• Renal Insufficiency: No dosage adjustment is necessary.
• Elderly Patients: Pharmacokinetics are similar between elderly and younger adults; no dosage adjustment is required.

Take this medication as advised by a registered physician.

Drug Interactions Aeron has been used alongside other common asthma treatments without an increased risk of adverse reactions. Drug interaction studies show that the recommended dose of Aeron does not significantly affect the pharmacokinetics of theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, or warfarin. However, drugs that induce hepatic metabolism, such as phenobarbital, may reduce the effectiveness of Aeron by decreasing its plasma concentration. Clinical monitoring is advised when combining Aeron with potent cytochrome P450 enzyme inducers like phenobarbital or rifampin.

Contraindications Aeron should not be used by individuals with known hypersensitivity to any of its components.

Side Effects

• Common: Diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, and upper respiratory tract infections.
• Uncommon: Anxiety, depression, dizziness, drowsiness, irritability, sleep disorders, dry mouth, muscle discomfort, and seizures.
• Rare: Angioedema, hallucinations, liver disorders, memory loss, palpitations, pulmonary eosinophilia, and suicidal tendencies.

Pregnancy & Lactation Montelukast crosses the placenta in animal studies, but there is limited data on its effects in pregnant women. It should be used during pregnancy only if necessary. As it may be excreted in breast milk, caution is advised when prescribing to nursing mothers.

Precautions & Warnings

• Aeron is not intended for the treatment of acute asthma attacks or status asthmaticus. Patients should always have a rescue inhaler available.
• Therapy with Aeron may continue during asthma exacerbations, but it should not be abruptly substituted for inhaled or oral corticosteroids.
• Aeron should not be used as the sole treatment for exercise-induced bronchospasm.
• Patients with aspirin sensitivity should continue avoiding aspirin and NSAIDs while using Aeron, as it does not prevent aspirin-induced bronchoconstriction.

Overdose Effects In case of overdose, most symptoms align with the known safety profile of Aeron and may include abdominal pain, drowsiness, thirst, headache, vomiting, and hyperactivity. Standard supportive measures should be taken, such as removing unabsorbed material from the digestive tract and monitoring the patient clinically.

Therapeutic Class Leukotriene receptor antagonists

Storage Conditions Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Chemical Information

• Molecular Formula: C35H36ClNO3S

Frequently Asked Questions

1. What is Aeron 10 mg Tablet?
   • Aeron is a selective and orally active leukotriene receptor antagonist used to manage asthma and allergic rhinitis.
2. What conditions does Aeron 10 mg Tablet treat?
   • It is primarily prescribed for asthma and allergic rhinitis to help keep airways open and improve breathing.
3. How soon does Aeron 10 mg Tablet take effect?
   • The effect begins within 1-3 hours after administration, but it is not meant for immediate asthma relief.
4. How long does the effect of Aeron 10 mg Tablet last?
   • The medication remains effective for approximately 24 hours.
5. Can Aeron 10 mg Tablet be taken on an empty stomach?
   • Yes, it can be taken with or without food as directed by your doctor.
6. What should I do if I miss a dose?
   • If you miss a dose, take it as soon as you remember. If it is nearly time for the next dose, skip the missed dose. Do not take a double dose.
7. Is Aeron 10 mg Tablet safe during pregnancy?
   • It should be used in pregnancy only if clearly needed. Consult your doctor before use.

General Instructions

• Follow your doctor’s prescribed dosage and schedule.
• Do not adjust or stop the medication without consulting your doctor.
• Aeron is not a fast-acting medication for asthma attacks—seek medical help for sudden breathing difficulties.
• Avoid triggers that may worsen asthma symptoms.
• Consult your doctor before taking Aeron if you are pregnant or breastfeeding.