Afun 1%

Description

Indications

Afun is indicated for the treatment of various dermatomycoses caused by dermatophytes, yeasts, molds, and other fungi. It is also effective in skin conditions that have developed secondary fungal infections.

Some specific conditions that can be treated with Afun include:

• Interdigital mycoses (e.g., athlete’s foot)
• Paronychias (associated with nail mycoses)
• Fungal infections in skin folds
• Candida vulvitis and Candida balanitis
• Pityriasis versicolor
• Erythrasma

Use this medication as per the advice of a registered physician.

Description

Afun is a broad-spectrum antifungal medication used to treat various skin infections caused by pathogenic dermatophytes, yeasts, and molds. Additionally, it has activity against certain gram-positive bacteria, including Staphylococci and Trichomonas.

Similar to other imidazole antifungals, Afun works by disrupting the permeability of fungal cell membranes. At lower concentrations, it inhibits ergosterol synthesis, an essential component of fungal cell walls. At higher concentrations, it causes direct membrane damage, leading to fungal cell death.

Pharmacology

Clotrimazole, the active ingredient in Afun, functions by damaging the fungal cell membrane’s permeability barrier. It inhibits ergosterol biosynthesis, which is crucial for maintaining the integrity and function of fungal cell walls. Without sufficient ergosterol, fungal cells cannot sustain their structure, leading to inhibited growth.

Beyond its antifungal effects, Clotrimazole also impacts other biological mechanisms, such as:

• Inhibiting sarcoplasmic reticulum Ca²⁺ ATPase
• Depleting intracellular calcium levels
• Blocking calcium-dependent potassium and voltage-gated calcium channels

These additional effects contribute to Clotrimazole’s pharmacological profile beyond its primary antifungal properties.

Dosage & Administration

Clotrimazole Cream

• Apply a thin layer to the affected area 2-3 times daily, rubbing it in gently.
• Due to its high efficacy, a small amount is sufficient for an area about the size of the palm.
• Consistent and prolonged application is crucial for successful treatment.

Recommended Duration of Treatment:

• Dermatomycoses: 3-4 weeks
• Candida vulvitis and Candida balanitis: 1-2 weeks
• Erythrasma and Pityriasis Versicolor: Approximately 3 weeks
• For fungal foot infections: Treatment should continue for 2 weeks beyond the disappearance of symptoms to prevent recurrence.

After washing, the feet should be thoroughly dried, particularly between the toes. Clotrimazole Cream is odorless, non-staining, and can be washed off easily.

Clotrimazole Topical Solution

• Apply sparingly to the affected area 2-3 times daily and rub in gently.

Use this medication as per the advice of a registered physician.

Drug Interactions

No significant drug interactions have been reported.

Contraindications

• Hypersensitivity to Clotrimazole or any of the excipients in the formulation.

Side Effects

Afun is generally well tolerated when applied topically. Systemic side effects are rare. In a few cases, localized irritation or a mild burning sensation may occur, but these symptoms are typically harmless.

Pregnancy & Lactation

• Clotrimazole should only be used during pregnancy if deemed necessary by a physician.
• Caution is advised when using Clotrimazole during lactation.

Therapeutic Class

• Drugs for subcutaneous and systemic mycoses
• Topical antifungal preparations

Storage Conditions

• Store below 25°C, away from light and moisture.
• Keep out of reach of children.