Anadol SR 100 mg

Description

Indications
Anadol SR is prescribed for the management of moderate to severe pain. It is commonly used for conditions such as:

• Postoperative pain
• Colic and spastic pain
• Cancer-related pain
• Joint pain
• Neck and back pain
• Pain associated with osteoporosis
  Use only as directed by a registered physician.

Pharmacology
Tramadol, the active ingredient in Anadol SR, is a centrally acting synthetic analgesic. It works by inhibiting the reuptake of serotonin and noradrenaline, thereby modifying pain signal transmission. The analgesic effect of Tramadol is mediated through stimulation of mu-opioid receptors and indirect modulation of central monoaminergic inhibitory pathways.

Dosage & Administration
Capsule or Tablet:

• The usual dose is 50 to 100 mg every 4 to 6 hours.
• For acute pain, an initial dose of 100 mg is recommended.
• For chronic pain, an initial dose of 50 mg is advised, followed by 50 to 100 mg every 4 to 6 hours as needed.
• The maximum daily oral dose should not exceed 400 mg.

Sustained Release (SR) Capsule or Tablet:

• Take one SR capsule or tablet every 12 hours (e.g., morning and evening).
• The number of capsules per dose depends on pain severity but should not be taken more frequently than every 12 hours.
• The total daily dose should not exceed 400 mg.

Injection:

• A dose of 50-100 mg may be administered every 4 to 6 hours via intramuscular injection or intravenous infusion.
• For postoperative pain, an initial dose of 100 mg is followed by 50 mg every 10 to 20 minutes if needed, with a maximum of 250 mg in the first hour.
• Thereafter, doses of 50 to 100 mg can be given every 4 to 6 hours, with a total daily dose not exceeding 600 mg.

Suppository:

• Tramadol suppositories should be administered rectally.
• The usual adult dose is 100 mg every 6 hours.
• A total daily dose of 400 mg (four 100 mg suppositories) is typically sufficient.
• In cases of cancer pain or severe postoperative pain, higher daily doses may be required.
  Use only as directed by a registered physician.

Drug Interactions

• Anadol SR generally has minimal drug interactions.
• However, it should not be combined with monoamine oxidase (MAO) inhibitors.
• Concurrent use of carbamazepine may increase the metabolism of Anadol SR, requiring a higher dose for effectiveness.

Contraindications
Anadol SR is contraindicated in individuals with:

• Known hypersensitivity to Tramadol
• Acute intoxication due to alcohol, hypnotics, opioids, centrally acting analgesics, or psychotropic drugs

Side Effects
Common side effects include:

• Dizziness, nausea, vomiting
• Constipation, headache, drowsiness
• Pruritus, sweating, dry mouth, diarrhea

Less common side effects include:

• Allergic reactions, weight loss, abdominal pain
• Palpitations, vasodilation, gastrointestinal bleeding
• Stomatitis, hepatitis

Pregnancy & Lactation

• The safety of Tramadol use during pregnancy has not been established. It crosses the placenta and should only be used if the potential benefit outweighs the risk to the fetus.
• Tramadol and its metabolites are excreted in breast milk; therefore, it is not recommended for breastfeeding mothers.

Precautions & Warnings

• Respiratory depression: High doses or concurrent use with anesthetics or alcohol can cause respiratory depression.
• Opioid dependence: Anadol SR is not suitable for opioid-dependent patients.
• CNS depressants: Use with alcohol, opioids, anesthetics, tranquilizers, or sedatives requires caution and dose adjustments.
• MAO inhibitors: Anadol SR should be used with extreme caution in patients taking MAO inhibitors, as Tramadol affects norepinephrine and serotonin levels.
• Head injuries and intracranial pressure: Caution is advised in patients with head injuries or increased intracranial pressure.
• Acute abdominal conditions: Use with caution in patients with acute abdominal pain.

Use in Special Populations

• Children aged 1 year and above: Anadol SR may be given at a dose of 1-2 mg/kg body weight.
• Children under 14 years: The suppository form (100 mg) should not be used.
• Anadol SR 100 mg SR Capsules have not been studied in children, so their safety and efficacy in pediatric patients remain unestablished.

Therapeutic Class
Opioid Analgesics

Storage Conditions

• Store below 30°C, away from light and moisture.
• Keep out of reach of children.