Anclog 75 mg

Description

Indications
Anclog is indicated for the following conditions:

• Acute Coronary Syndrome (ACS): It is used to reduce the incidence of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS, including unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI). Anclog is also indicated to reduce the risk of MI and stroke in patients with acute ST-elevation myocardial infarction (STEMI).
• Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: In patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Anclog is used to reduce the risk of MI and stroke.

Use this medication as advised by a registered physician.

Pharmacology
Clopidogrel, the active ingredient in Anclog, is a prodrug that works by inhibiting platelet activation and aggregation. It achieves this through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.

• The inhibition of platelet aggregation begins within 2 hours of a single oral dose.
• Repeated daily doses of 75 mg inhibit ADP-induced platelet aggregation from the first day of treatment, and steady-state inhibition is achieved between Day 3 and Day 7.

Dosage & Administration

• Acute Coronary Syndrome: For patients requiring an antiplatelet effect within hours, initiate treatment with a single 300 mg oral loading dose (equivalent to 4 tablets), followed by 75 mg once daily. Starting without a loading dose will delay the onset of antiplatelet action.
• Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: The standard dose is 75 mg once daily without the need for a loading dose.

Anclog can be taken orally, with or without food.

Use this medication as advised by a registered physician.

Interactions

• NSAIDs, warfarin, SSRIs, SNRIs: These may increase the risk of bleeding when used with Anclog.
• CYP2C19 inhibitors (e.g., omeprazole, esomeprazole): Avoid using Anclog alongside these drugs, as they can reduce the effectiveness of clopidogrel.
• Repaglinide (CYP2C8 substrates): The use of Anclog with repaglinide should be avoided due to the potential increase in plasma concentrations of repaglinide.

Contraindications
Anclog should not be used in the following cases:

• Hypersensitivity to clopidogrel or any of the components of the formulation.
• Active pathological bleeding, such as from peptic ulcers or intracranial hemorrhage.

Side Effects
Anclog is generally well tolerated, but common side effects may include:

• Bleeding
• Diarrhea
• Gastrointestinal discomfort
• Hemorrhage
• Skin reactions

Rare side effects include:

• Acquired hemophilia
• Anemia
• Angioedema
• Arthralgia
• Arthritis
• Bone marrow disorders

Pregnancy & Lactation
There are no well-controlled studies on the use of Anclog in pregnant women. It should only be used during pregnancy if the benefit clearly outweighs the potential risks to the fetus. The safety of clopidogrel in human breast milk is not known. A decision should be made whether to discontinue breastfeeding or to stop the drug, taking into consideration the importance of the drug to the mother.

Precautions & Warnings

• CYP2C19 Variations: As a prodrug, clopidogrel’s conversion to its active metabolite can be impaired in patients with genetic variations (poor metabolizers) of the CYP2C19 enzyme or when used alongside CYP2C19 inhibitors like omeprazole or esomeprazole. This may reduce the drug’s effectiveness.
• Risk of Bleeding: Anclog inhibits platelet aggregation for the lifetime of the platelet (7-10 days), increasing the risk of bleeding. Platelet transfusions may be less effective if performed within 4 hours of a loading dose or 2 hours of a maintenance dose.
• Discontinuation: Stopping Anclog suddenly may increase the risk of cardiovascular events. Discontinue 5 days before elective surgery with a major risk of bleeding. Resume Anclog as soon as hemostasis is achieved.
• Thrombotic Thrombocytopenic Purpura (TTP): TTP has been reported in some cases, requiring urgent treatment such as plasmapheresis.
• Hypersensitivity Reactions: Rash, angioedema, or hematologic reactions may occur, especially in patients with a history of hypersensitivity to other thienopyridines.

Use in Special Populations

• Pediatric Use: The safety and effectiveness of Anclog in children have not been established.
• Elderly: No dosage adjustments are required for elderly patients.

Overdose Effects
Overdose of Anclog may result in bleeding complications. Based on clinical evidence, platelet transfusion may help restore normal clotting function.

Therapeutic Class
Anti-platelet drugs

Storage Conditions
Store below 30°C, in a dry place, protected from light. Do not freeze. Keep out of the reach of children.