Angilock 50 mg

Description

Indications
Hypertension: Angilock Tablet is prescribed for the management of high blood pressure. It can be used alone or in combination with other antihypertensive medications, such as thiazide diuretics.

Renal Protection in Type-2 Diabetic Patients with Proteinuria: Angilock Tablet is also indicated to slow the progression of kidney disease in hypertensive patients with type-2 diabetes who have proteinuria, defined as a urinary albumin-to-creatinine ratio exceeding 300 mg/g.

Take this medication as per the advice of a registered physician.

Pharmacology
Losartan Potassium is the first orally active, non-peptide angiotensin II receptor blocker (ARB). It selectively binds to the AT1 receptor present in various tissues, including vascular smooth muscle, adrenal glands, kidneys, and the heart. By blocking angiotensin II at this receptor site, Losartan Potassium reduces vasoconstriction and the release of aldosterone, both of which contribute to hypertension.

Dosage & Administration

• The typical starting and maintenance dose for most patients is 50 mg once daily.
• If the desired antihypertensive effect is not achieved with 50 mg once daily, an alternative dosing regimen of 25 mg twice daily may be considered before increasing the dose further.
• For patients experiencing intravascular volume depletion (e.g., those on high-dose diuretics), an initial dose of 25 mg once daily is recommended.
• The medication can be taken once or twice daily, with a total daily dose ranging from 25 mg to 100 mg.

Special Populations:

• Patients up to 75 years: No dose adjustment is needed.
• Patients over 75 years: Due to limited clinical data, a lower starting dose of 25 mg once daily is recommended.

Take this medication as per the advice of a registered physician.

Drug Interactions

• Rifampicin and fluconazole may lower the levels of the active metabolite of Angilock.
• Concurrent use with hydrochlorothiazide may enhance antihypertensive effects.
• Combining Angilock with potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increased serum potassium levels.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin may reduce the antihypertensive effects of Losartan.
• The simultaneous use of an ACE inhibitor, an angiotensin receptor blocker (ARB), a non-steroidal anti-inflammatory drug (NSAID), and a thiazide diuretic increases the risk of kidney dysfunction.

Contraindications

• Angilock is contraindicated in pregnant women.
• Patients with known hypersensitivity to Losartan Potassium or any component of the formulation should avoid its use.
• It should not be taken alongside Aliskiren in patients with diabetes.

Side Effects
Angilock is generally well tolerated, and side effects are usually mild and temporary. Common side effects include:

• Dizziness
• Diarrhea
• Nasal congestion
• Cough
• Upper respiratory tract infections
  Other possible side effects include fatigue, swelling (edema), abdominal pain, chest pain, nausea, headache, and sore throat (pharyngitis).

Use in Pregnancy & Lactation

• Pregnancy Category D: The use of Angilock during the second and third trimesters of pregnancy may cause fetal harm, including impaired kidney function, increased fetal and neonatal morbidity, or even death.
• It is unclear whether Losartan is excreted in human breast milk. Considering the potential risk to the nursing infant, a decision should be made whether to discontinue breastfeeding or discontinue the medication, based on the mother’s clinical needs.

Precautions & Warnings

• Using Angilock during the second and third trimesters of pregnancy may result in fetal kidney impairment and increase the risk of fetal and neonatal complications or mortality.
• Patients with intravascular volume depletion (e.g., those on high-dose diuretics) may experience symptomatic low blood pressure.
• Losartan levels are significantly increased in patients with liver disease, necessitating caution.
• Changes in kidney function, including potential kidney failure, have been reported in patients with renal impairment.

Use in Special Populations

• Patients with renal impairment: No dose adjustment is necessary for mild renal impairment (creatinine clearance 20–50 ml/min). However, for those with moderate to severe renal impairment (creatinine clearance <20 ml/min) or those undergoing dialysis, a lower starting dose of 25 mg once daily is recommended.
• Patients with intravascular volume depletion: Those with significant volume depletion (e.g., due to high-dose diuretics) should start with 25 mg once daily.
• Patients with liver impairment: A reduced dose should be considered for individuals with liver disease.

Therapeutic Class
Angiotensin II Receptor Blockers (ARBs)

Storage Conditions

• Store in a cool, dry place, away from direct light and heat.
• Keep out of the reach of children.