Arovent 10 mg

Description

Indications Arovent is prescribed for:

• Long-term management and prevention of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms associated with Allergic Rhinitis (AR), including both seasonal and perennial allergic rhinitis

Pharmacology Montelukast is a selective leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). Leukotrienes (LTC4, LTD4, LTE4) are inflammatory mediators derived from arachidonic acid and released by immune cells such as mast cells and eosinophils. These mediators contribute to airway inflammation, smooth muscle constriction, and edema, which are characteristic of asthma and allergic rhinitis. By blocking leukotriene activity, Montelukast helps reduce inflammation and improve airway function.

Dosage & Administration

For Adults and Adolescents (15 years and older)

• 10 mg tablet once daily

For Pediatric Patients with Asthma or Seasonal Allergic Rhinitis

• 6 to 14 years: 5 mg tablet once daily
• 2 to 5 years: 4 mg tablet once daily
• 6 months to 5 years: 4 mg oral granules once daily (can be administered directly or mixed with a spoonful of cold water or soft food at room temperature)

Use in Pediatric Patients Montelukast has been evaluated in children aged 6 months to 14 years, showing similar safety and efficacy profiles as in adults.

Patients with Hepatic or Renal Insufficiency

• No dosage adjustment is needed for mild-to-moderate hepatic insufficiency or renal impairment.

Elderly Patients

• No dosage adjustment required, though the plasma half-life may be slightly longer in elderly individuals.

Drug Interactions Arovent can be used alongside standard asthma treatments without a notable increase in adverse effects. Clinical studies have shown that it does not significantly alter the pharmacokinetics of drugs such as theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, or warfarin. However, enzyme inducers like phenobarbital may reduce Montelukast levels by approximately 40%. Although no dosage adjustment is necessary, careful monitoring is advised when used with potent cytochrome P450 enzyme inducers such as phenobarbital or rifampin.

Contraindications Arovent is contraindicated in individuals with hypersensitivity to Montelukast or any of its components.

Side Effects

Common Side Effects:

• Headache, nausea, vomiting, diarrhea, fever, gastrointestinal discomfort, upper respiratory tract infection, and skin reactions.

Uncommon Side Effects:

• Anxiety, irritability, dizziness, drowsiness, muscle pain, joint pain, dry mouth, abnormal behavior, sleep disturbances, and edema.

Rare Side Effects:

• Angioedema, hallucinations, liver disorders, memory impairment, palpitations, pulmonary eosinophilia, and suicidal tendencies.

Pregnancy & Lactation Montelukast crosses the placenta in animal studies, but no adequate human studies exist. It should be used during pregnancy only if clearly necessary. Since Montelukast may be excreted in breast milk, caution is advised when administering it to nursing mothers.

Precautions & Warnings

• Arovent is not intended for the treatment of acute asthma attacks. Patients should have a fast-acting rescue inhaler available for sudden breathing difficulties.
• It should not be abruptly substituted for corticosteroids.
• It is not recommended as monotherapy for exercise-induced bronchospasm.
• Patients with aspirin sensitivity should continue avoiding aspirin and NSAIDs while on Arovent.

Overdose Effects Overdose cases have not shown significant adverse effects. Reported symptoms include abdominal pain, thirst, drowsiness, vomiting, and psychomotor hyperactivity. Supportive care should be provided in case of an overdose.

Therapeutic Class Leukotriene receptor antagonists

Storage Conditions

• Store below 30°C in a cool, dry place.
• Protect from light and moisture.
• Keep out of reach of children.

Frequently Asked Questions

What is Arovent 10 mg Tablet used for? Arovent is commonly used for managing asthma and allergic rhinitis by blocking leukotrienes to improve airway function.

How long does Arovent take to work? The effects can be observed within 1-3 hours after administration, with an average duration of 24 hours. It is not a rescue medication for asthma attacks.

Can Arovent be taken on an empty stomach? Yes, it can be taken with or without food.

What if I miss a dose? Take the missed dose as soon as possible. If it is close to your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is Arovent safe during pregnancy? Arovent should be used in pregnancy only if necessary and after consulting a doctor.

General Instructions

• Take Arovent exactly as prescribed by your doctor.
• Do not stop or adjust the dosage without consulting your doctor.
• If asthma symptoms worsen, seek medical attention immediately.
• Avoid triggers that may exacerbate asthma symptoms.
• Consult your doctor before using Arovent if you are pregnant or breastfeeding.