Asmadox Tablet 200 mg

Description

Indications
Asmadox is indicated for the treatment of:

• Bronchial asthma
• Bronchospasm
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary disease with a spastic bronchial component

Use this medication only as directed by a registered physician.

Pharmacology
Asmadox contains Doxophylline, a novel bronchodilator that differs structurally from Theophylline due to the presence of a dioxolane group at position 7. Doxophylline selectively inhibits phosphodiesterase 4 (PDE4), leading to the relaxation of bronchial smooth muscle. Unlike Theophylline, Doxophylline has a lower affinity for adenosine A1 and A2 receptors, contributing to its better safety profile. Doxophylline is also known to inhibit platelet-activating factor (PAF) and reduce leukotriene production.

Dosage & Administration

• Elderly: 200 mg tablet two or three times daily.
• Adults: 400 mg tablet two or three times daily, or as prescribed by the physician.
• Children:
  • Over 12 years: 10 ml syrup or 200 mg tablet two or three times daily.
  • 6-12 years: 6-9 mg/kg body weight twice daily (for a child weighing 10 kg, 3 ml (60 mg) twice daily), or as prescribed by the physician.
  • If a daily dose of 400 mg is required, sustained-release (SR) tablets should be taken once daily or as prescribed by the physician.

Use this medication only as directed by a registered physician.

Interaction
Asmadox should not be used with other xanthine derivatives. It is recommended to limit the intake of caffeine-containing beverages and foods. Caution should be exercised when taking Asmadox together with ephedrine or other sympathomimetic drugs. The concurrent administration of medications like erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol may reduce the liver clearance of xanthine derivatives, increasing their plasma levels. Phenytoin, other anticonvulsants, and cigarette smoking may increase the clearance of xanthine derivatives, lowering plasma half-life, which may require dosage adjustments.

Contraindications
Asmadox is contraindicated in individuals with:

• Known hypersensitivity to Doxophylline or other xanthine derivatives
• Acute myocardial infarction
• Hypotension
• Lactation

Side Effects
Patients treated with xanthine derivatives may experience:

• Common: Nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, extrasystoles, tachypnea
• Rare: Hyperglycemia, albuminuria
• Overdose Symptoms: Severe cardiac arrhythmias and tonic-clonic seizures may occur, which are early signs of intoxication. If side effects appear, discontinuation of the drug may be necessary, and treatment may be resumed at lower doses under the physician’s discretion once the symptoms subside.

Pregnancy & Lactation
Animal studies show that Doxophylline does not interfere with pre- or postnatal growth. However, due to insufficient clinical data, its use during pregnancy should be assessed on a case-by-case basis, weighing the risk-benefit ratio. Asmadox is contraindicated during lactation.

Effects on Driving & Machine Operation
Asmadox does not impair alertness, so it does not affect the ability to drive or operate machinery.

Precautions & Warnings
Various factors may reduce the hepatic clearance of xanthine derivatives, increasing plasma levels, including:

• Age
• Congestive cardiac decompensation
• Chronic obstructive pulmonary disease
• Severe liver disease
• Concomitant infections
• Concurrent use of erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol

In such cases, reducing the dosage and monitoring blood levels of the drug is recommended to maintain therapeutic efficacy.

Special Caution Required for Patients with:

• Cardiac disease
• Hypertension
• Severe hypoxemia
• Hyperthyroidism
• Chronic corpulmonale
• Congestive heart failure
• Liver disease
• Peptic ulcer
• Renal impairment

In congestive heart failure, drug clearance is slower, and high plasma levels may persist, even after discontinuation of treatment. No risk of addiction or dependence.

Overdose Effects
In overdose cases, cardiac arrhythmias and tonic-clonic seizures may occur. These are early signs of intoxication. As there is no specific antidote, symptomatic treatment for cardiovascular collapse should be initiated.

Therapeutic Class
Bronchodilator, Methyl xanthine derivatives

Storage Conditions
Store in a dry place, away from light and heat. Keep out of reach of children. Asmadox should only be used on the prescription of a specialist physician.