Atova 10 mg

Description

Indications

Atova is prescribed as an adjunct to dietary measures to lower elevated levels of total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides in cases where diet and other non-pharmacological interventions prove insufficient.

• Reduces total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolemia.
• Lowers elevated cholesterol and triglycerides in patients with mixed dyslipidemia (Fredrickson Type Ia and Ib).
• Treats elevated serum triglyceride levels in hypertriglyceridemia (Fredrickson Type IV).
• Manages dysbetalipoproteinemia (Fredrickson Type III).
• Reduces cardiac ischemic events in individuals with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL cholesterol levels.
• Helps lower total and LDL cholesterol in cases of hypercholesterolemia associated with diabetes mellitus or renal transplantation.

Take this medication only as advised by a registered physician.

Pharmacology Atorvastatin, the active ingredient in Atova, is a selective inhibitor of HMG-CoA reductase, the enzyme responsible for converting HMG-CoA to mevalonate, a precursor of cholesterol. It works by reducing cholesterol synthesis in the liver and increasing hepatic LDL receptor activity, leading to enhanced uptake and degradation of LDL cholesterol.

• Absorption: Rapidly absorbed after oral intake, reaching peak plasma concentrations within 1 to 2 hours. Bioavailability is approximately 14%.
• Distribution: Atorvastatin has a mean volume of distribution of approximately 381 liters and is 98% bound to plasma proteins.
• Metabolism: Primarily metabolized into active ortho- and parahydroxylated derivatives through the cytochrome P450 3A4 enzyme pathway.
• Excretion: Eliminated mainly via bile, with a half-life of about 14 hours and extended inhibitory activity due to active metabolites.

Dosage & Administration

• Primary Hypercholesterolemia and Combined Hyperlipidemia:
  • Adults: Start with 10 mg once daily, increasing up to 80 mg daily if needed.
  • Children (10-18 years): Begin with 10 mg daily, with a maximum of 20 mg daily.
• Familial Hypercholesterolemia:
  • Adults: Start at 10 mg daily, increasing up to 80 mg if required.
  • Children (10-18 years): Initial dose of 10 mg daily, with a maximum of 80 mg.
• Prevention of Cardiovascular Events:
  • Adults: Start at 10 mg daily, adjusting based on response.

Patients should follow a cholesterol-lowering diet before and during treatment. Lipid levels should be monitored 2 to 4 weeks after initiation to adjust dosage accordingly.

Drug Interactions

• Increased risk of myopathy: When taken with cyclosporine, fibric acid derivatives, niacin, erythromycin, or azole antifungals.
• Antacid: Co-administration decreases atorvastatin plasma concentration by approximately 35% but does not affect LDL reduction.
• Colestipol: Reduces atorvastatin plasma levels by 25% but enhances LDL reduction.
• Digoxin: Increases plasma digoxin levels by about 20%; monitoring is advised.
• Erythromycin: Increases atorvastatin plasma concentration by 40%.
• Oral Contraceptives: Increases norethindrone and ethinyl estradiol levels by 30% and 20%, respectively.
• Warfarin: No significant effect on prothrombin time.

Contraindications Atova should not be used in individuals with:

• Hypersensitivity to any component of the medication.
• Active liver disease or unexplained persistent elevations of serum transaminases.
• A history of serious adverse reactions to HMG-CoA reductase inhibitors.

Side Effects Common side effects include constipation, flatulence, dyspepsia, and abdominal pain. Less common effects include headache, rash, myalgia, and arthralgia.

Pregnancy & Lactation

• Pregnancy: Atova is contraindicated as it may harm fetal development. Treatment should be discontinued if pregnancy is suspected or confirmed.
• Lactation: It is unknown whether atorvastatin passes into human milk. Due to potential adverse effects, breastfeeding while on Atova is not recommended.

Precautions & Warnings

• Liver Function: Liver function tests should be conducted before starting therapy and periodically thereafter. Caution is advised for patients with liver disease or high alcohol consumption.
• Muscle Effects: If unexplained muscle pain or weakness occurs, Atova should be discontinued immediately.

Use in Special Populations

• Elderly: Higher plasma concentrations are observed in individuals over 65, with an increased LDL-lowering effect.
• Pediatrics: Limited pharmacokinetic data available; caution is advised.
• Renal Impairment: No dosage adjustment is necessary.
• Hemodialysis: Unlikely to significantly enhance drug clearance.
• Hepatic Impairment: Markedly increased plasma concentrations in patients with liver disease.

Overdose Effects No specific antidote is available for Atova overdose. Symptomatic and supportive treatment should be provided, with liver function and CK levels monitored. Hemodialysis is not expected to be effective due to high plasma protein binding.

Therapeutic Class Statins, Anti-anginal, and Anti-ischemic drugs.

Storage Conditions Store in a dry place away from direct heat and light. Keep out of reach of children.

Common Questions about Atova 10 mg Tablet

• What is Atova 10 mg Tablet?
  • A statin medication used to lower cholesterol levels and reduce cardiovascular risks.
• How should I take Atova 10 mg Tablet?
  • Take it once daily, with or without food, preferably at the same time each day.
• Does Atova 10 mg Tablet cause weight loss?
  • Weight loss is not a common side effect; consult a doctor if it occurs.
• Can I stop taking Atova 10 mg Tablet?
  • Do not stop without consulting your doctor, as discontinuation may worsen your condition.
• Is Atova 10 mg Tablet safe for long-term use?
  • Yes, when taken as prescribed by a healthcare professional.
• Can Atova 10 mg Tablet be given to children?
  • It can be used in children over 10 years old under medical supervision.