Axibid 500 mg

Description

Indications
This medication is used for the treatment of bacterial infections caused by bacteria that are susceptible to it.
It is effective in treating:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes.
• Acute Bacterial Sinusitis caused by susceptible organisms such as Streptococcus pneumoniae and others.
• Chronic Bronchitis exacerbated by bacterial infections, and several other bacterial infections, as per the treating physician’s recommendations.

Note: Always use as prescribed by a registered healthcare provider.

Pharmacology
Cefuroxime is an effective, broad-spectrum antibiotic with bactericidal properties. It works against a wide variety of pathogens, including strains that produce beta-lactamase, an enzyme that can make bacteria resistant to many common antibiotics. Due to its ability to resist degradation by bacterial beta-lactamases, it is effective against a number of strains resistant to ampicillin and amoxicillin.

Dosage

• Tablet or Suspension:

  • Adults and Adolescents (13 years and older):

    • Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
    • Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
    • Acute Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
    • Skin and Skin Structure Infections: 250-500 mg twice daily for 10 days.
    • Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
    • Gonorrhoea: A single dose of 1000 mg.
    • Community Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
    • MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
    • Early Lyme Disease: 500 mg twice daily for 20 days.

  • Pediatric (3 months to 12 years):

    • Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days.
    • Acute Otitis Media: 30 mg/kg/day twice daily for 10 days.
    • Impetigo: 30 mg/kg/day twice daily for 10 days.

• Parenteral (Injection):

  • Adults: 750 mg 3 times a day via IM or IV injection. For severe infections, the dose may be increased to 1.5 gm 3 times daily. Total daily doses may be increased up to 3-6 gm.
  • Children (above 3 months): 30-100 mg/kg/day divided into 3-4 doses. A typical dose is 60 mg/kg/day.
  • Neonates: 30-100 mg/kg/day, divided into 2-3 doses.
  • Surgical Prophylaxis: 1.5 gm IV at the induction of anesthesia, followed by 750 mg every 8 hours for high-risk surgeries.
  • Pneumonia: 1.5 gm IV twice daily for 2-3 days, followed by 500 mg twice daily (oral) for 7-10 days.
  • Acute Exacerbations of Chronic Bronchitis: 750 mg twice daily (IM or IV) for 2-3 days, followed by 500 mg twice daily (oral) for 5-10 days.
  • Gonorrhoea: 1.5 gm as a single dose via two 750 mg intramuscular injections at different sites.

  In Meningitis:

  • Adults: 3 gm IV 3 times daily.
  • Children (above 3 months): 200-240 mg/kg/day IV, divided into 3-4 doses, reduced to 100 mg/kg/day after clinical improvement.
  • Neonates: 100 mg/kg/day IV initially, reduced to 50 mg/kg/day once clinically indicated.

  In Bone and Joint Infections:

  • Adults: 1.5 gm IV four times daily.
  • Children (above 3 months): 150 mg/kg/day (not exceeding the adult dose) divided every 8 hours.

Administration
For the best results, freshly reconstituted solutions should be used. The potency of the solution is maintained for up to 24 hours at room temperature or 48 hours when stored at 5°C.

Drug Interactions
No significant hazardous drug interactions have been reported.

Contraindications
This medication is contraindicated for individuals with a known allergy to cephalosporins.

Side Effects
Cefuroxime (Axibid) is generally well tolerated. Rare side effects include rashes and gastrointestinal disturbances. As with other antibiotics, prolonged use may encourage the growth of non-susceptible organisms like Candida.

Pregnancy and Lactation
Cefuroxime belongs to FDA Pregnancy Category B. While no comprehensive controlled studies in pregnant women exist, animal studies have not shown evidence of harm. This medication should only be used during pregnancy when clearly needed. It is excreted in human milk, so caution is recommended when administering this drug to breastfeeding women.

Precautions and Warnings

• Caution is advised for patients taking potent diuretics or those with a history of colitis.
• Hypersensitivity: Although cephalosporins can generally be used in patients allergic to penicillin, cross-reactivity is possible. The recommended dose levels of Axibid are unlikely to cause such issues.

Therapeutic Class
Second-generation cephalosporins.

Reconstitution Instructions

• For 750 mg Intramuscular Injection, add 3 ml of water for injection to the vial and shake gently to disperse.
• For 750 mg Intravenous Injection, add 8 ml of water for injection to the vial and shake gently. Inject slowly into the vein over a 3-5 minute period.
• For 1.5 gm Intravenous Injection, add 16 ml of water for injection to the vial and shake gently. Inject slowly into the vein over 3-5 minutes.

Storage Conditions
Store the product in a cool, dry place, below 30°C, away from light and moisture. Keep out of reach of children.

Always follow the directions of your healthcare provider when using this medication.