Calboral-D Tablet 500 mg+200 IU

Description

Indications
Calboral-D tablet is indicated for the treatment and prevention of:

• Osteoporosis
• Osteomalacia
• Tetany
• Hypoparathyroidism
• Disorders of osteogenesis

It is also used as a supplement in cases of inadequate calcium intake in childhood diets, rickets, pregnancy, lactation, and elderly patients. Additional indications include pancreatitis and as a phosphate binder in chronic renal failure.

Use the medication as directed by a registered healthcare professional.

Composition
Each tablet contains:

• Calcium Carbonate USP 1250 mg (Coral source) equivalent to 500 mg of elemental Calcium & Vitamin D USP 200 IU.

Each DX tablet contains:

• Calcium Carbonate USP 1500 mg (Coral source) equivalent to 600 mg of elemental Calcium & Vitamin D USP 400 IU.

Each effervescent tablet contains:

• Calcium Carbonate (Coral source) USP 1500 mg equivalent to 600 mg of elemental Calcium and Vitamin D3 400 IU as Cholecalciferol USP.

Pharmacology
Calcium is essential for a variety of bodily functions, and deficiencies can have serious consequences. Clinical evidence suggests that Calcium is effective in preventing and treating Osteoporosis and related fractures. Vitamin D aids in the absorption of Calcium from the gastrointestinal tract and stimulates bone formation. Studies indicate that Calcium and Vitamin D work synergistically to promote bone growth and prevent fractures. The Calcium Carbonate in this preparation is derived from coral, which has a chemical structure similar to human bone, ensuring better absorption. Vitamin D3 helps maintain Calcium balance in the body.

Dosage & Administration

• One tablet once or twice daily with plenty of water or as directed by a physician. Taking it on a full stomach ensures better absorption.
• Dissolve one effervescent tablet in a glass of water and drink immediately after stirring.

Use the medication as directed by a registered healthcare professional.

Interaction

• Thiazide diuretics: Reduce urinary calcium excretion, increasing the risk of hypercalcemia. Serum calcium should be monitored regularly.
• Systemic corticosteroids: Decrease calcium absorption, potentially requiring a dose adjustment.
• Ion exchange resins (e.g., cholestyramine) & laxatives (e.g., paraffin oil): May reduce Vitamin D absorption.
• Tetracycline preparations: Calcium interferes with absorption; tetracyclines should be taken at least two hours before or four to six hours after Calcium intake.
• Cardiac glycosides (e.g., Digoxin): Hypercalcemia may increase toxicity; ECG and calcium levels should be monitored.
• Bisphosphonates & sodium fluoride: Calcium should be taken at least three hours before these medications to prevent reduced absorption.
• Oxalic acid (in spinach, rhubarb) & phytic acid (in whole cereals): May inhibit Calcium absorption. Calcium products should not be taken within two hours of consuming these foods.

Contraindications

• Hypercalcemia and hyperparathyroidism
• Hypercalciuria and nephrolithiasis
• Hypersensitivity to any components of the preparation
• Severe renal insufficiency
• Concomitant Digoxin therapy (requires careful monitoring of serum Calcium levels)

Side Effects

• Gastrointestinal irritation, constipation
• Rarely, hypercalcemia in patients with chronic renal failure
• Allergic reactions, irregular heartbeat, nausea, vomiting, decreased appetite, dry mouth, drowsiness
• Occasional skin rash with Vitamin D supplementation

Pregnancy & Lactation

• Daily intake should not exceed 1500 mg Calcium and 600 IU Cholecalciferol during pregnancy.
• High doses of Vitamin D may cause reproductive toxicity.
• Overdoses of Calcium and Vitamin D should be avoided due to potential adverse effects on the fetus.
• At therapeutic doses, Vitamin D is not teratogenic.
• Elemental Calcium & Vitamin D3 tablet can be used during pregnancy and breastfeeding if there is a deficiency, but the presence of Vitamin D3 in breast milk should be considered when supplementing the infant.

Precautions & Warnings

• Long-term treatment requires monitoring of serum Calcium levels and renal function.
• Elderly patients, those on cardiac glycosides or diuretics, and those prone to kidney stones should be closely monitored.
• Hypercalcemia or impaired renal function may require dose reduction or discontinuation.
• Patients with renal impairment should be cautious, as Vitamin D metabolism may be affected.
• Patients with sarcoidosis should be monitored for increased metabolism of Vitamin D.
• Immobilized osteoporosis patients have a higher risk of hypercalcemia.
• Additional Calcium or Vitamin D intake should be supervised by a physician.

Overdose Effects
Overdose may result in hypervitaminosis D and hypercalcemia. Symptoms include:

• Anorexia, thirst, nausea, vomiting, constipation, abdominal pain
• Muscle weakness, fatigue, mental disturbances
• Polydipsia, polyuria, bone pain, nephrocalcinosis, nephrolithiasis
• Severe cases may lead to cardiac arrhythmias, coma, and death
• Persistent hypercalcemia can cause irreversible renal damage and soft tissue calcification

Treatment of Hypercalcemia

• Discontinue Calcium, Thiazide diuretics, Lithium, Vitamin A, and cardiac glycosides.
• Stomach emptying for unconscious patients.
• Rehydration, with possible use of loop diuretics, bisphosphonates, calcitonin, and corticosteroids.
• Monitor serum electrolytes, renal function, diuresis, ECG, and central venous pressure.

Therapeutic Class
Specific mineral and vitamin combined preparations.

Storage Conditions

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.

Common Questions About Calboral-D 500 mg Tablet

What is Calboral-D 500 mg Tablet?
Calboral-D 500 mg Tablet is a combination of Calcium Carbonate and Vitamin D3. It is used to prevent and treat Calcium and Vitamin D deficiencies. Calcium is essential for strong bones and teeth, while Vitamin D enhances Calcium absorption.

What are the benefits of taking Calboral-D 500 mg Tablet?

• Prevention and treatment of Calcium and Vitamin D deficiency
• Prevention of Osteoporosis
• Treatment of Rickets and Osteomalacia
• Improved bone health in elderly individuals

Who should not take Calboral-D 500 mg Tablet?

• Individuals with high Calcium or Vitamin D levels in the blood
• Those with kidney stones
• Patients with sarcoidosis
• Individuals allergic to any ingredients of Calboral-D

What are the side effects of Calboral-D 500 mg Tablet?

• Constipation, nausea, vomiting, diarrhea
• Headache, drowsiness, dry mouth

How should I take Calboral-D 500 mg Tablet?

• Take with food, one tablet per day, or as prescribed by a physician.

What precautions should I take before using Calboral-D 500 mg Tablet?

• Avoid if pregnant or breastfeeding without medical supervision.
• Do not use if you have hypercalcemia, kidney stones, or an allergy to any ingredients.