Ceevit DS 500 mg

Description

Indications

Ascorbic Acid (Ceevit DS) is indicated for:

• Prevention and treatment of scurvy.
• Helps in healing wounds and broken bones.
• Aids in the formation of collagen in connective tissues.
• Enhances iron absorption and aids in the treatment of anemia.
• Contributes to the production of hemoglobin and red blood cells in the bone marrow.
• Helps in preventing and managing viral and bacterial infections, boosting the immune system.
• Assists in the prevention and treatment of the common cold.
• Promotes healthy capillaries, gums, and teeth.

Always use as directed by a registered healthcare provider.

Pharmacology

Ceevit DS contains Ascorbic Acid (Vitamin C), a vital nutrient that the body cannot produce, meaning it must be obtained from diet or supplements. Vitamin C has numerous important functions:

• Tissue growth and repair: Vital for healthy growth and repair of tissues in the body.
• Adrenal gland function: Supports normal adrenal gland function.
• Enhanced immunity: Strengthens the immune system and helps protect against infections.
• Antioxidant protection: Provides protection from harmful pollution and infection, reducing cellular damage.
• Wound healing: Acts as a coenzyme, necessary for the healing of wounds and the metabolism of drugs, cholesterol, and folic acid.
• Collagen formation: Essential for healthy hair, skin, and gums.
• Metabolism: Important in maintaining overall health and wellbeing.

Dosage & Administration

• Oral tablet administration:

  • For the prevention of scurvy: 1 tablet daily.
  • For the treatment of scurvy: 1-2 tablets daily, with the dose adjusted based on the severity.
  • For reducing the risk of stroke in the elderly: 1-2 tablets daily.
  • In other cases: 1 tablet daily or as prescribed by a physician.
  • Maximum safe dose: 2000 mg daily, in divided doses.

• Oral sachet administration:

  • 1 sachet daily or as directed by a registered physician.
  • Maximum dose: 2000 mg/day (up to 4 sachets/day).

• Parenteral administration (IM, IV, or subcutaneously):

  • Ascorbic Acid is primarily administered orally; however, when oral intake is not possible, it can be given parenterally.
  • For intravenous injection: Dilute the solution into a large volume (e.g., Normal Saline, Water for Injection, or Glucose) to reduce adverse reactions.
  • Average protective dose for adults: 70-150 mg daily.
  • For scurvy: 300 mg to 1 g daily.
  • For wound healing: 300-500 mg daily for 7-10 days.
  • For severe burns: Daily doses of 1-2 g are recommended.
  • Larger doses are recommended in cases where the need for vitamin C is significantly increased.

Parenteral drug products should be visually inspected for particulate matter or discoloration before administration.

Interaction

• Potentially hazardous interactions: Ascorbic acid is incompatible in solution with medications such as aminophylline, bleomycin, erythromycin, and others. Ensure proper compatibility before administration.
• Useful interactions: Ascorbic acid can increase the half-life of paracetamol and enhance iron absorption from the gastrointestinal tract.

Side Effects

• General: Ceevit DS is generally safe, with little toxicity. However, large doses may cause:
  • Diarrhea, abdominal bloating, and iron over-absorption, especially in patients with conditions like thalassemia, sideroblastic anemia, and hemochromatosis.
  • Hyperoxaluria, hyperuricosuria, and hemolysis may occur in patients with glucose-6-phosphate dehydrogenase deficiency.
  • Excessive doses (more than 5 g/day) during pregnancy can result in fetal abortion.

Pregnancy & Lactation

• Pregnancy: Vitamin C is safe when taken in normal doses during pregnancy. However, taking more than 5 g per day may cause abortion.
• Lactation: Vitamin C can be taken safely during breastfeeding.

Precautions & Warnings

• Mega-doses (more than 1000 mg daily) during pregnancy have been associated with scurvy in neonates.
• Contraindicated for patients with hyperoxaluria due to the risk of developing kidney stones.
• Ascorbic acid can cause false positive reactions in certain analytical tests for glucose, uric acid, creatinine, and occult blood.

Therapeutic Class

Vitamin C Preparations

Storage Conditions

• Store in a dry place, below 30°C, away from light and moisture.