Cefaclav (125 mg+31.25 mg)/5 ml

Description

Indications

Cefaclav is a combination antibiotic indicated for the treatment of various infections caused by susceptible bacteria. It is effective in managing the following conditions:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media: Caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis: Caused by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase producing strains).
• Lower Respiratory Tract Infections: Including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Klebsiella spp., Staphylococcus aureus (both penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli.
• Acute Bacterial Exacerbation of Chronic Bronchitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (non-beta-lactamase strains), or Haemophilus parainfluenzae (non-beta-lactamase strains).
• Uncomplicated Skin and Skin Structure Infections: Caused by Staphylococcus aureus (including beta-lactamase-producing strains) or Streptococcus pyogenes.
• Uncomplicated Urinary Tract Infections: Caused by E. coli or Klebsiella pneumoniae.
• Bone and Joint Infections: Caused by Staphylococcus aureus (both penicillinase- and non-penicillinase-producing strains).
• Uncomplicated Gonorrhea: Caused by both penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae.
• Early Lyme Disease (Erythema Migrans): Caused by Borrelia burgdorferi.
• Septicemia: Caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
• Meningitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (both penicillinase- and non-penicillinase-producing strains).

Switch Therapy (Injectable to Oral)
Follow your registered physician’s advice for proper medication use.

Pharmacology

Cefaclav combines Cefuroxime, a second-generation cephalosporin antibiotic, with Clavulanic acid, a beta-lactamase inhibitor.

• Cefuroxime is a bactericidal agent that targets bacterial cell wall synthesis by inhibiting transpeptidation, effective against a broad spectrum of Gram-positive and Gram-negative organisms, including many beta-lactamase-producing strains.
• Clavulanic acid, produced by Streptomyces clavuligerus, inhibits beta-lactamase enzymes. It prevents the degradation of Cefuroxime, thereby enabling effective treatment against beta-lactam-resistant bacteria.

Dosage and Administration

For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
• Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
• Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
• Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
• Uncomplicated Skin and Skin Structure Infections: 250-500 mg twice daily for 10 days.
• Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
• Uncomplicated Gonorrhea: 1000 mg twice daily, single dose.
• Community Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
• Early Lyme Disease (Erythema Migrans): 500 mg twice daily for 20 days.

For Paediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days.
• Acute Otitis Media: 30 mg/kg/day twice daily for 10 days.
• Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day twice daily for 10 days.
• Impetigo: 30 mg/kg/day twice daily for 10 days.

Cefuroxime-Clavulanic Acid tablets can be taken regardless of food intake.

Follow your registered physician’s advice for proper medication use.

Interactions

When taken alongside probenecid, the area under the serum concentration-time curve of Cefuroxime increases by 50%. Medications that reduce gastric acidity may lower the bioavailability of Cefuroxime, diminishing the effects of postprandial absorption.

Contraindications

Cefuroxime-Clavulanic Acid should not be used by patients with a known allergy to cephalosporins or those suffering from Pseudomembranous Colitis.

Side Effects

Cefuroxime-Clavulanic Acid is generally well tolerated. However, some side effects may occur, including nausea, vomiting, diarrhea, and abdominal discomfort. Prolonged use can lead to overgrowth of non-susceptible microorganisms. Rare side effects (<0.2%) include renal dysfunction, anaphylaxis, angioedema, pruritus, rash, and serum sickness-like urticaria.

Pregnancy and Lactation

While antibiotics are best avoided during the first trimester of pregnancy, Cefuroxime-Clavulanic Acid is considered safe for use during later stages to treat urinary and other infections. It is excreted into breast milk in small amounts; caution should be taken to monitor for potential sensitization in the infant.

Precautions and Warnings

Cefuroxime should be administered cautiously in patients on concurrent potent diuretics or those with a history of colitis.

Therapeutic Class

Second-generation cephalosporins, vaccines, anti-sera, and immunoglobulins.

Storage Conditions

Store in a cool, dry place, away from light and moisture (below 30°C). Keep out of the reach of children.

Common Questions about Cefaclav 125 Syrup

• What is Cefaclav 125 Syrup?
  Cefaclav 125 Syrup contains Cefuroxime, a cephalosporin antibiotic, and Clavulanic acid, a beta-lactamase inhibitor. It is used to treat infections caused by bacteria that are susceptible to these ingredients.

• How long does it take for Cefaclav 125 Syrup to work?
  It typically starts working within 2-3 hours after administration.

• How long do the effects of Cefaclav 125 Syrup last?
  The effects generally last for 4-8 hours.

• Can I consume alcohol while taking this medicine?
  The interaction between alcohol and Cefaclav 125 Syrup is not well known, so it is advisable to consult your doctor before drinking alcohol.

• Is Cefaclav 125 Syrup habit-forming?
  No, there have been no reports of habit-forming tendencies.

• Can Cefaclav 125 Syrup be taken during pregnancy?
  Yes, it is safe to use during pregnancy to treat bacterial infections, but it is important to consult your doctor before use.

• Can Cefaclav 125 Syrup be taken while breastfeeding?
  Yes, it is safe to use while breastfeeding, as it only enters breast milk in small amounts.

Quick Tips

• Complete the full course of treatment as prescribed, even if you feel better before finishing it. Stopping early may cause the infection to return and become harder to treat.
• Take with food to avoid an upset stomach.
• Watch for diarrhea as a side effect. Probiotics may help, but consult your doctor if you experience severe symptoms like bloody stools or abdominal cramps.
• Seek immediate medical attention if you develop an itchy rash, swelling of the face, throat, or tongue, or difficulty breathing while taking this medication.
• Do not reuse leftover medication to treat future infections. Always consult your doctor before taking any antibiotics.