Cefaclav 500 mg+125 mg

Description

Indications
Cefaclav 500 mg Tablet is prescribed for the treatment of bacterial infections caused by susceptible microorganisms, including:

• Pharyngitis/Tonsillitis due to Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis.
• Acute Bacterial Exacerbation of Chronic Bronchitis.
• Secondary Bacterial Infections of Acute Bronchitis.
• Skin and Soft Tissue Infections.
• Uncomplicated Urinary Tract Infections (UTIs).
• Uncomplicated Gonorrhea.
• Community-Acquired Pneumonia.
• Multi-Drug Resistant (MDR) Typhoid Fever.
• Early Lyme Disease.

Pharmacology
Cefaclav 500 mg Tablet contains Cefuroxime, a second-generation cephalosporin antibiotic with bactericidal properties. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains. Cefuroxime works by inhibiting bacterial cell wall synthesis, disrupting the transpeptidation process essential for bacterial survival.

Clavulanic acid, a beta-lactamase inhibitor derived from Streptomyces clavuligerus, helps protect Cefuroxime from degradation by beta-lactamase enzymes. By irreversibly binding to these enzymes, Clavulanic acid extends Cefuroxime’s efficacy against resistant bacteria.

Dosage & Administration
For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
• Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
• Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
• Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
• Uncomplicated Skin and Soft Tissue Infections: 250-500 mg twice daily for 10 days.
• Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
• Uncomplicated Gonorrhea: 1000 mg as a single dose.
• Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
• Early Lyme Disease: 500 mg twice daily for 20 days.

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days.
• Acute Otitis Media: 30 mg/kg/day in two divided doses for 10 days.
• Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day in two divided doses for 10 days.
• Impetigo: 30 mg/kg/day in two divided doses for 10 days.

Cefuroxime-Clavulanic Acid tablets can be taken with or without food.

Drug Interactions

• Concurrent use of Probenecid increases Cefuroxime’s serum concentration by approximately 50%.
• Medications that reduce gastric acidity may lower Cefuroxime’s bioavailability and reduce its postprandial absorption.

Contraindications

• Patients with a known allergy to cephalosporin antibiotics.
• Individuals with a history of Pseudomembranous Colitis.

Side Effects
Cefaclav 500 mg Tablet is generally well tolerated, though some patients may experience:

• Nausea, vomiting, diarrhea, abdominal discomfort, or pain.
• Prolonged use may lead to the overgrowth of nonsusceptible microorganisms.
• Rare occurrences (<0.2%) of renal dysfunction, anaphylaxis, angioedema, pruritus, rash, or serum sickness-like urticaria.

Pregnancy & Lactation

• Though antibiotics should ideally be avoided during the first trimester, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat bacterial infections.
• This medication is excreted in small amounts into breast milk; therefore, caution is advised to prevent sensitization in infants.

Precautions & Warnings

• Administer with caution in patients receiving concurrent diuretic therapy.
• Use with care in individuals with a history of colitis.

Therapeutic Class

• Second-Generation Cephalosporins.
• Vaccines, Anti-sera & Immunoglobulins.

Storage Conditions

• Store below 30°C in a cool, dry place away from moisture and direct light.
• Keep out of reach of children.

Frequently Asked Questions (FAQs)
What is Cefaclav 500 mg Tablet?
Cefaclav 500 mg Tablet is a combination of Cefuroxime, a cephalosporin antibiotic, and Clavulanic acid, a beta-lactamase inhibitor. It is used to treat bacterial infections caused by susceptible bacteria.

What conditions does Cefaclav 500 mg Tablet treat?
This medication is used to treat infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, skin infections, urinary tract infections, gonorrhea, pneumonia, and typhoid fever.

How long does Cefaclav 500 mg Tablet take to work?
The onset of action is typically within 2-3 hours after administration.

How long do the effects last?
The effects generally last for 4-8 hours.

Can I consume alcohol while taking Cefaclav 500 mg Tablet?
There is no known interaction between alcohol and this medication, but it is advisable to consult a healthcare provider before consuming alcohol.

Is Cefaclav 500 mg Tablet habit-forming?
No habit-forming tendencies have been reported for this medication.

Is this medication safe during pregnancy?
Yes, Cefaclav 500 mg Tablet is considered safe for use during pregnancy to treat bacterial infections, but it should only be used after consulting a doctor.

Can this medicine be taken while breastfeeding?
Yes, it is generally safe for breastfeeding mothers, though small amounts may pass into breast milk.

Quick Tips

• Take the full course of medication as prescribed, even if you feel better, to prevent resistance.
• Take with food to minimize stomach discomfort.
• If diarrhea occurs, consider using probiotics and consult a doctor if symptoms persist or worsen.
• Discontinue use and seek medical attention if signs of an allergic reaction occur, such as rash, facial swelling, or difficulty breathing.
• Do not use leftover medication for future infections—always consult a doctor before taking antibiotics again.