Cefim-3 100 mg/5 ml

Description

Indications
Cefim-3 is an orally active cephalosporin antibiotic with significant bactericidal activity against a broad range of Gram-positive and Gram-negative organisms. It is indicated for treating acute infections caused by susceptible microorganisms, including:

• Upper Respiratory Tract Infections (URTI): e.g., otitis media and other URTIs resistant to common antibiotics or where treatment failure poses significant risks.
• Lower Respiratory Tract Infections: e.g., bronchitis.
• Urinary Tract Infections: e.g., cystitis, cystourethritis, pyelonephritis.

Clinical efficacy has been shown against pathogens such as Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (both beta-lactamase positive and negative), Moraxella catarrhalis (both beta-lactamase positive and negative), and Enterobacter species. Cefim-3 is highly stable in the presence of beta-lactamase enzymes.
Use under the guidance of a registered physician.

Pharmacology
Cefim-3 is a third-generation semisynthetic cephalosporin antibiotic that acts bactericidally by inhibiting bacterial cell wall synthesis. It is effective against both Gram-positive and Gram-negative bacteria at plasma concentrations easily achievable in humans. Cefixime remains stable against beta-lactamase enzymes, which allows it to treat infections caused by organisms resistant to penicillins and some cephalosporins. Its absorption is around 40-50%, whether taken with or without food.

Dosage & Administration

• Adults and Children over 10 years: The recommended dose is 200-400 mg per day, either as a single dose or divided into two doses, depending on infection severity.
• Elderly: Same dosage as adults, with adjustments made for severe renal impairment.
• Children:
  • 6 months to 1 year: 3.75 ml daily
  • 1-4 years: 5 ml daily
  • 5-10 years: 10 ml daily
  • For typhoid, 5 mg/kg twice daily for 10-14 days.
  • Children above 50 kg or over 10 years should receive the adult dose.
• Renal Impairment:
  • For creatinine clearance >20 ml/min: Regular dosing.
  • For creatinine clearance <20 ml/min: Limit to 200 mg once daily.

Use under the guidance of a registered physician.

Interaction
Cefim-3 can increase prothrombin times in some patients, particularly those on anticoagulant therapy. Exercise caution in such cases.

Contraindications

• Hypersensitivity to cephalosporin antibiotics.

Side Effects
Cefim-3 is generally well tolerated, but side effects may include:

• Gastrointestinal: Diarrhea, nausea, abdominal pain, vomiting, dyspepsia, flatulence.
• CNS: Headache, dizziness.
• Allergic: Rash, pruritus, urticaria, drug fever, arthralgia.
• Hematological: Thrombocytopenia, leukopenia, eosinophilia (rare).
• Other: Mild liver or renal function changes, genital pruritus, vaginitis.

Pregnancy & Lactation
There are no well-controlled studies in pregnant women. Cefim-3 should only be used during pregnancy if clearly needed. The excretion of Cefim-3 in human milk is not known; caution is advised when used during breastfeeding.

Precautions & Warnings

• Use with caution in patients allergic to penicillin, as there may be cross-reactivity between penicillins and cephalosporins.
• Caution in patients with severe renal impairment.
• Prolonged use may lead to overgrowth of Clostridium difficile, resulting in antibiotic-associated diarrhea.
• Not recommended in pregnant or breastfeeding women unless deemed essential by a doctor.

Overdose Effects
No specific antidote. Gastric lavage may be necessary. Cefim-3 is not significantly removed by dialysis. Overdosing on up to 2g of Cefim-3 has not shown significant adverse effects compared to standard dosing.

Therapeutic Class
Third-generation cephalosporins.

Storage Conditions
Store below 30ºC, away from light and moisture. Keep out of reach of children.

Chemical Structure

• Molecular Formula: C16H15N5O7S2
• Chemical Structure: Cefixime Trihydrate.

Common Questions about Cefim-3 100 mg/5 ml Suspension

• What is Cefim-3 100 mg/5 ml Syrup?
  Cefim-3 is an antibiotic used for bacterial infections. It works by disrupting the bacterial cell wall, essential for their survival.

• What are the uses of Cefim-3 Syrup?
  It is used for treating urinary tract infections, tonsillitis, pharyngitis, bronchitis, and certain fungal and gonococcal infections.

• What are the side effects of Cefim-3 Syrup?
  Side effects may include diarrhea, abdominal pain, swelling of the face or lips, dizziness, indigestion, chest pain, and unusual tiredness.

• Storage Instructions
  Keep in a cool, dry place, away from children, and dispose of expired medicine properly.

• Can Cefim-3 treat colds or flu?
  No, it is ineffective against viral infections like colds and flu.

• Can I take Cefim-3 with acetaminophen?
  No interactions have been found, but consult your doctor before using together.

Quick Tips

• Finish the full course even if symptoms improve.
• Take with food to prevent stomach upset.
• Inform your doctor if diarrhea persists or if blood is present in stools.
• Avoid alcohol during treatment, as it may increase side effects.
• Discontinue immediately and consult your doctor if you experience a rash, swelling, or difficulty breathing.