Cefim-3 200 mg

Description

Indications

Cefim-3 is an orally administered cephalosporin antibiotic with potent bactericidal activity against a broad range of Gram-positive and Gram-negative bacteria. It is prescribed for the treatment of various acute infections caused by susceptible microorganisms.

Upper Respiratory Tract Infections (URTI): Conditions such as otitis media and other upper respiratory tract infections, especially when the causative pathogen is suspected to be resistant to common antibiotics or when treatment failure may pose significant risks.

Lower Respiratory Tract Infections: Includes infections like bronchitis.

Urinary Tract Infections (UTI): Such as cystitis, cystourethritis, and pyelonephritis. Clinical studies have shown efficacy against pathogens including Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), and Enterobacter species. Cefim-3 remains highly stable in the presence of beta-lactamase enzymes.

Take medication as prescribed by a registered physician.

Pharmacology

Cefixime, the active ingredient in Cefim-3, is a third-generation cephalosporin antibiotic designed for oral use. It exhibits bactericidal properties by disrupting bacterial cell wall synthesis. It is particularly effective against various Gram-positive and Gram-negative bacteria and is highly resistant to degradation by beta-lactamase enzymes. This makes it a suitable option for treating infections caused by beta-lactamase-producing bacteria. Its absorption rate ranges between 40% and 50%, regardless of food intake.

Dosage & Administration

Cefixime absorption is not significantly affected by food. The standard treatment duration is 7 days, though it may be extended up to 14 days if necessary.

Adults and Children Over 10 Years: Recommended dosage is 200-400 mg daily, depending on infection severity, administered as a single dose or divided into two doses.

Elderly: The same dosage as adults can be followed. Renal function assessment is advised, with dosage adjustment in cases of severe renal impairment.

Children:

• 6 months to 1 year: 3.75 ml daily
• 1 to 4 years: 5 ml daily
• 5 to 10 years: 10 ml daily
• Children over 50 kg or older than 10 years: Follow adult dosage recommendations (200-400 mg daily).

Typhoid Fever: 5 mg/kg body weight twice daily for 10-14 days.

Infants under 6 months: Safety and efficacy have not been established.

Renal Impairment: For patients with creatinine clearance of 20 ml/min or higher, the standard dosage can be maintained. If clearance is below 20 ml/min, a maximum daily dose of 200 mg is recommended. The same guideline applies to patients undergoing chronic ambulatory peritoneal dialysis or hemodialysis.

Take medication as prescribed by a registered physician.

Drug Interactions

As with other cephalosporins, Cefim-3 may cause an increase in prothrombin time in some patients. Caution is advised for individuals undergoing anticoagulant therapy.

Contraindications

Cefim-3 should not be used in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Cefim-3 is generally well-tolerated. Reported side effects are typically mild and self-limiting.

Gastrointestinal: The most common side effect is diarrhea, especially at higher doses. Other possible issues include nausea, abdominal pain, dyspepsia, vomiting, and flatulence. Rarely, pseudomembranous colitis may occur.

Central Nervous System: Headache and dizziness.

Hypersensitivity Reactions: Allergic reactions such as rash, pruritus, urticaria, drug fever, and arthralgia. Symptoms usually resolve upon discontinuation of the drug.

Hematological: Rare cases of thrombocytopenia, leukopenia, and eosinophilia, which are generally reversible.

Miscellaneous: Other possible reactions include genital itching and vaginitis.

Pregnancy & Lactation

There are no adequate, well-controlled studies of Cefixime use in pregnant women. As animal studies do not always predict human response, Cefixime should be used during pregnancy only if necessary. It is not known whether Cefixime is excreted in human milk, so caution is advised when prescribing to nursing mothers.

Precautions & Warnings

• Cefim-3 should be used with caution in patients with known drug allergies, particularly those allergic to penicillins, due to potential cross-reactivity.
• If an allergic reaction occurs, discontinue use and provide appropriate medical treatment.
• Caution is advised in patients with significantly impaired renal function.
• Broad-spectrum antibiotics can disrupt normal gut flora, potentially leading to overgrowth of Clostridium difficile, a primary cause of antibiotic-associated diarrhea.

Overdose Effects

There is no specific antidote for Cefim-3 overdose. Gastric lavage may be considered if necessary. Cefixime is not effectively removed through hemodialysis or peritoneal dialysis. Clinical trials have shown that doses up to 2 g in healthy adults did not produce significantly different adverse effects compared to standard therapeutic doses.

Therapeutic Class

Third-generation Cephalosporins.

Storage Conditions

• Store below 30ºC, away from light and moisture.
• Keep out of the reach of children.

Common Questions About Cefim-3 200 mg Capsule

What is Cefim-3 200 mg Capsule? Cefim-3 is an antibiotic used to treat bacterial infections. It does not work for viral infections such as the flu. It acts by inhibiting bacterial cell wall synthesis, essential for bacterial survival.

What conditions does Cefim-3 200 mg Capsule treat? It is prescribed for urinary tract infections, tonsillitis, pharyngitis, and bronchitis. It may also be used for some fungal and gonococcal infections.

What are the possible side effects? Common side effects include diarrhea, abdominal pain, dizziness, indigestion, gas, redness of the skin, sore throat, and unusual tiredness. If severe allergic reactions occur, seek medical attention immediately.

How should Cefim-3 be stored and disposed of? Store in a cool, dry place, away from children and pets. Dispose of unused or expired medication properly to prevent health risks.

Can Cefim-3 be used to treat cold and flu? No, Cefim-3 is an antibiotic and does not work against viral infections like colds and flu.

Is there any special dietary advice while taking Cefim-3? No special dietary restrictions unless advised by your doctor.

Is Cefim-3 safe for infants? The safety of Cefim-3 in infants under 6 months has not been established. Consult a doctor before use.

Is Cefim-3 related to penicillin? No, Cefim-3 is a cephalosporin antibiotic, not a penicillin derivative. However, there may be cross-reactivity in penicillin-allergic patients.

Does Cefim-3 cause diarrhea? Diarrhea is a known side effect, especially at higher doses.

Can Cefim-3 interact with contraceptives? There is no evidence suggesting an interaction between Cefim-3 and contraceptive pills.

Can I take acetaminophen with Cefim-3? No known interactions exist, but consult a doctor before combining medications.

How long does Cefim-3 take to work? It begins working shortly after ingestion, but full symptom relief may take a few days. Complete the prescribed course to prevent antibiotic resistance.

What if my condition does not improve after taking Cefim-3? If symptoms persist or worsen, consult your doctor.

Quick Tips

• Complete the full course even if you feel better.
• Take with food to reduce stomach upset.
• Avoid alcohol to prevent side effects.
• Report any allergic reactions immediately.