Ceftid 100 mg/5 ml

Indications:

Ceftid is an orally active cephalosporin antibiotic with significant in-vitro bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It is indicated for treating various acute infections caused by susceptible microorganisms:

• Upper Respiratory Tract Infections (URTI): For conditions like otitis media and other URTIs where the causative organism is resistant to commonly used antibiotics or where treatment failure could pose significant risk.
• Lower Respiratory Tract Infections: Such as bronchitis.
• Urinary Tract Infections (UTI): Including cystitis, cystourethritis, and pyelonephritis. Proven efficacy against pathogens such as Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella species, and Haemophilus influenzae (both beta-lactamase positive and negative).

Pharmacology:

Cefixime is a third-generation semisynthetic cephalosporin antibiotic for oral administration. It is bactericidal against a broad spectrum of both Gram-positive and Gram-negative bacteria at achievable plasma concentrations. It kills bacteria by disrupting the synthesis of the bacterial cell wall and is highly stable against beta-lactamase enzymes. This allows Cefixime to be effective against bacteria resistant to penicillins and some cephalosporins. Its absorption is about 40% to 50%, regardless of food intake.

Dosage & Administration:

• Adults and children over 10 years: 200-400 mg daily, either as a single dose or in two divided doses.
• Elderly: Can take the same dose as adults, but renal function should be assessed, and adjustments may be needed in cases of severe renal impairment.
• Children:
  • 6 months to 1 year: 3.75 ml daily.
  • 1-4 years: 5 ml daily.
  • 5-10 years: 10 ml daily.
  • For typhoid: 5 mg/kg body weight twice daily for 10-14 days.
  • Children over 50 kg or older than 10 years: Same as adult dosage.
• Renal Impairment:
  • Normal dose for creatinine clearance ≥20 ml/min.
  • In cases of creatinine clearance <20 ml/min, limit to a maximum of 200 mg once daily.

Interactions:

Cefixime may increase prothrombin times in some patients, particularly when combined with anticoagulant therapy.

Contraindications:

• Known hypersensitivity to cephalosporins.

Side Effects:

Common and mild side effects include:

• Gastrointestinal: Diarrhea, nausea, abdominal pain, and vomiting.
• Central Nervous System: Headache and dizziness.
• Hypersensitivity Reactions: Rash, pruritis, urticaria, and drug fever.
• Hematological: Thrombocytopenia, leukopenia, eosinophilia (rare and reversible).

Pregnancy & Lactation:

• No adequate studies in pregnant women; use only if necessary.
• Cefixime may be excreted in human milk. Exercise caution when administering to breastfeeding women.

Precautions & Warnings:

• Use with caution in patients with known hypersensitivity to other drugs, particularly penicillins.
• Caution in patients with impaired renal function.
• Risk of Clostridium difficile-associated diarrhea due to broad-spectrum antibiotic use.

Overdose Effects:

• No specific antidote; gastric lavage may be considered.
• Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.

Storage Conditions:

• Store below 30ºC, protected from light and moisture. Keep out of reach of children.

Common Questions:

• What is Ceftid 100 mg/5 ml Syrup?
  Ceftid 100 mg/5 ml Syrup is an antibiotic used to treat bacterial infections, not viral ones like the flu.

• What are the side effects of Ceftid 100 mg/5 ml Syrup?
  Possible side effects include diarrhea, abdominal pain, dizziness, and allergic reactions. Severe side effects such as swelling or breathing difficulties should be addressed immediately.

• Can I take acetaminophen with Ceftid 100 mg/5 ml Syrup?
  No known interactions exist, but consult a doctor before combining them.

Quick Tips:

• Complete the full course of treatment to avoid the development of resistant infections.
• Avoid alcohol during treatment to prevent increased side effects.
• If you notice severe side effects, such as rash or difficulty breathing, discontinue the medication and consult your doctor immediately.