Ceftid 200 mg

Description

Indications

Ceftid is an orally active cephalosporin antibiotic with significant in-vitro bactericidal activity against a broad range of Gram-positive and Gram-negative organisms. It is indicated for the treatment of the following acute infections caused by susceptible microorganisms:

• Upper Respiratory Tract Infections (URTI): e.g., otitis media and other URTIs where the causative organism is resistant to other commonly used antibiotics or where treatment failure carries significant risk.
• Lower Respiratory Tract Infections (LRTI): e.g., bronchitis.
• Urinary Tract Infections (UTI): e.g., cystitis, cystourethritis, pyelonephritis.

It is effective against common pathogens such as Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), and Enterobacter species. Ceftid is highly stable in the presence of beta-lactamase enzymes.

Always take as directed by a registered healthcare provider.

Pharmacology

Ceftid (Cefixime) is a third-generation semisynthetic cephalosporin antibiotic used for oral administration. It has a bactericidal effect against a wide spectrum of Gram-positive and Gram-negative bacteria by inhibiting the synthesis of the bacterial cell wall.

• Absorption: Approximately 40-50% is absorbed, whether taken with or without food.
• Beta-lactamase stability: It remains effective against organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases.

Dosage & Administration

• Adults and children over 10 years: The usual recommended dosage is 200-400 mg daily depending on the severity of the infection, administered as a single dose or divided into two doses.
• Elderly: The same dosage as adults can be used, but renal function should be assessed, and dosage may need to be adjusted in cases of severe renal impairment.
• Children:
  • 6 months to 1 year: 3.75 ml daily.
  • 1-4 years: 5 ml daily.
  • 5-10 years: 10 ml daily.
  • Typhoid (children): 5 mg/kg body weight twice daily for 10-14 days.
  • Children over 10 years or weighing more than 50 kg: Treated with the adult dosage (200-400 mg daily).
  • Children under 6 months: Safety and efficacy have not been established in this age group.
• Renal Impairment:
  • Normal dosing can be used for patients with creatinine clearance of 20 ml/min or greater.
  • For those with creatinine clearance less than 20 ml/min, the recommended dose is 200 mg once daily, with no more than this dose.
  • For patients on chronic ambulatory peritoneal dialysis or hemodialysis, the dosing recommendations for impaired renal function should be followed.

Interaction

• Anticoagulants: Ceftid may increase prothrombin times in a few patients, especially those on anticoagulant therapy, so caution is advised.

Contraindications

• Hypersensitivity to cephalosporin antibiotics.

Side Effects

Ceftid is generally well-tolerated, but side effects may include:

• Gastrointestinal disturbances: Diarrhea (most common, especially at higher doses), nausea, abdominal pain, dyspepsia, vomiting, flatulence, and pseudomembranous colitis.
• Central nervous system: Headache and dizziness.
• Hypersensitivity reactions: Rash, pruritus, urticaria, drug fever, and arthralgia (usually resolve upon discontinuation of therapy).
• Hematological and clinical chemistry: Thrombocytopenia, leukopenia, and eosinophilia (reversible).
• Liver and renal function: Mild, transient changes in function tests.
• Miscellaneous: Genital pruritus and vaginitis.

Pregnancy & Lactation

• There are no adequate and well-controlled studies in pregnant women. The drug should only be used during pregnancy if clearly needed.
• It is not known whether Ceftid is excreted in human milk. Caution is advised when administered to a nursing woman.

Precautions & Warnings

• Hypersensitivity: Ceftid should be used with caution in patients who have shown hypersensitivity to other drugs. Cephalosporins may show partial cross-reactivity in patients sensitive to penicillins.
• Renal function: Caution is needed for patients with markedly impaired renal function.
• Clostridium difficile-associated diarrhea: As with other broad-spectrum antibiotics, Ceftid may alter the normal flora of the colon, promoting Clostridium difficile overgrowth and resulting in antibiotic-associated diarrhea.

Overdose Effects

• Gastric lavage may be necessary. There is no specific antidote for overdose.
• Ceftid is not significantly removed from circulation by hemodialysis or peritoneal dialysis.
• Adverse reactions were not significantly different in healthy adults who received single doses up to 2 g compared to patients on the recommended doses.

Therapeutic Class

• Third-generation Cephalosporins

Storage Conditions

• Store below 30°C, protected from light and moisture.
• Keep out of reach of children.

Chemical Structure

• Molecular Formula: C16H15N5O7S2

Frequently Asked Questions

What is Ceftid 200 mg Capsule? Ceftid 200 mg Capsule is an antibiotic used to treat bacterial infections. It prevents bacteria from forming the cell wall they need for growth.

Can I take Ceftid 200 mg Capsule to treat the flu or a cold? No, Ceftid is an antibiotic, and it does not work for viral infections such as the flu or a cold.

What should I do if I don’t feel better after taking Ceftid 200 mg Capsule? If you don’t feel better or if your symptoms worsen, contact your doctor for further advice.

Can I drink alcohol while taking Ceftid 200 mg Capsule? It is advised to avoid alcohol during treatment with Ceftid, as it may increase side effects.

Is Ceftid 200 mg Capsule safe for children? It is safe for children over 6 months. The safety of Ceftid has not been established for infants under 6 months.