Cerox CV 500 mg+125 mg

Description

Indications:

Cerox CV 500 mg Tablet is prescribed for the treatment of bacterial infections caused by sensitive organisms. It is specifically used for managing:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media: Caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase producing strains), or Streptococcus pyogenes.
• Acute Bacterial Sinusitis: Caused by common bacterial pathogens.
• Acute Exacerbation of Chronic Bronchitis: Often resulting from bacterial infection.
• Uncomplicated Skin and Soft Tissue Infections (SSTI): Caused by susceptible bacteria.
• Urinary Tract Infections (UTI): Including uncomplicated cases.
• Gonorrhea: Treatment of uncomplicated gonorrheal infections.
• Community-Acquired Pneumonia: Caused by various sensitive bacteria.
• MDR Typhoid Fever: Infections resistant to certain antibiotics.
• Early Lyme Disease: Treatment during the early stages of infection.

Pharmacology:

Cerox CV 500 mg Tablet combines Cefuroxime and Clavulanic Acid for enhanced antimicrobial activity:

• Cefuroxime: A broad-spectrum, second-generation cephalosporin antibiotic, is bactericidal and effective against a wide range of Gram-positive and Gram-negative bacteria, including many strains that produce beta-lactamase. It works by inhibiting bacterial cell wall synthesis, particularly targeting the transpeptidation process.

• Clavulanic Acid: A potent beta-lactamase inhibitor derived from Streptomyces clavuligerus. By irreversibly binding to beta-lactamase enzymes, it prevents the degradation of Cefuroxime, allowing it to work effectively against beta-lactam-resistant bacteria.

Dosage and Administration:

• For Adolescents and Adults (13 years and older):

  • Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
  • Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
  • Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
  • Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
  • Uncomplicated Skin and Skin Structure Infections: 250-500 mg twice daily for 10 days.
  • Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
  • Uncomplicated Gonorrhea: 1000 mg as a single dose.
  • Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
  • MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
  • Early Lyme Disease: 500 mg twice daily for 20 days.

• For Paediatric Patients (3 months to 12 years):

  • Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days.
  • Acute Otitis Media: 30 mg/kg/day twice daily for 10 days.
  • Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day twice daily for 10 days.
  • Impetigo: 30 mg/kg/day twice daily for 10 days.

Cefuroxime-Clavulanic Acid can be taken with or without food.

Interaction:

• Probenecid: Co-administration with probenecid increases serum concentration of Cefuroxime by 50%.
• Drugs Reducing Gastric Acidity: Medications that reduce stomach acid may lower the absorption and bioavailability of Cefuroxime.

Contraindications:

• Allergy to Cephalosporins: Do not use Cerox CV if you have a known hypersensitivity to cephalosporin antibiotics.
• Pseudomembranous Colitis: Contraindicated in patients with a history of this condition.

Side Effects:

Cerox CV is generally well tolerated, but some side effects may include:

• Common Effects: Nausea, vomiting, diarrhea, abdominal discomfort or pain.
• Rare Effects (<0.2%): Renal dysfunction, anaphylaxis, angioedema, rash, pruritis, and serum sickness-like reactions (e.g., urticaria).

Prolonged use may lead to the overgrowth of non-susceptible organisms, including Candida.

Pregnancy & Lactation:

• Pregnancy: Cerox CV can be safely used during later stages of pregnancy for treating infections, particularly urinary and other infections. However, avoid its use during the first trimester unless necessary. Always consult a doctor before use.
• Lactation: The drug passes into breast milk in small amounts. While it is generally considered safe for breastfeeding mothers, caution is advised to avoid potential sensitization of the infant.

Precautions & Warnings:

• Renal Function: Caution should be exercised in patients with impaired renal function, especially those on diuretics or with a history of colitis.
• Hypersensitivity: Though rare, cross-reactivity may occur between cephalosporins and penicillins. Cerox CV is generally safe for patients allergic to penicillin at recommended doses.

Therapeutic Class:

• Second-generation Cephalosporins, Vaccines, Anti-sera, and Immunoglobulins.

Storage Conditions:

Store Cerox CV in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Common Questions about Cerox CV 500 mg Tablet:

• What is Cerox CV 500 mg Tablet? Cerox CV is a combination of Cefuroxime (a cephalosporin antibiotic) and Clavulanic Acid (a beta-lactamase inhibitor). It is prescribed to treat various bacterial infections caused by susceptible organisms.

• How long does it take for Cerox CV to show effects? The medicine begins to work within 2-3 hours after administration.

• Can I consume alcohol while taking Cerox CV? The interaction between alcohol and Cerox CV is not well-studied. It is recommended to consult a doctor before consuming alcohol during treatment.

• Is Cerox CV habit-forming? No, Cerox CV does not cause habit formation.

• Can Cerox CV be taken during pregnancy? It is generally safe to use during later stages of pregnancy, but always consult your healthcare provider before use.

• Can Cerox CV be used while breastfeeding? Yes, Cerox CV is considered safe to use while breastfeeding, but caution is advised due to its excretion in breast milk.

Quick Tips:

• Always complete the prescribed course of Cerox CV, even if you start feeling better, to ensure the infection is fully treated.
• Take the medicine with food to avoid any stomach upset.
• Diarrhea may occur; taking probiotics may help alleviate this. Consult your doctor if you experience severe diarrhea or blood in your stool.
• If you develop any signs of a severe allergic reaction, such as a rash, swelling of the face, tongue, or throat, or difficulty breathing, stop taking Cerox CV and contact your healthcare provider immediately.