Clavurox 250 mg+62.5 mg

Description

Clavurox 250 mg Tablet is indicated for the treatment of infections caused by bacteria sensitive to its components. These include:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis.
• Acute Bacterial Exacerbation of Chronic Bronchitis.
• Secondary Bacterial Infections of Acute Bronchitis.
• Uncomplicated Skin and Skin Structure Infections.
• Uncomplicated Urinary Tract Infections.
• Uncomplicated Gonorrhoea.
• Community-Acquired Pneumonia.
• MDR Typhoid Fever.
• Early Lyme Disease.

Use only as directed by a registered healthcare provider.

Pharmacology
Clavurox combines Cefuroxime, a bactericidal second-generation cephalosporin antibiotic, with Clavulanic Acid, a beta-lactamase inhibitor.

• Cefuroxime is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including many strains that produce beta-lactamase enzymes. It works by inhibiting bacterial cell wall synthesis through interference with the transpeptidation process.

• Clavulanic Acid is derived from Streptomyces clavuligerus. It structurally resembles beta-lactam antibiotics and binds irreversibly to beta-lactamase enzymes, inactivating them. This protects Cefuroxime from degradation by beta-lactamase enzymes, allowing it to treat infections caused by beta-lactam-resistant bacteria.

Dosage & Administration

• Adults and Adolescents (13 years and older):
  • Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
  • Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
  • Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
  • Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
  • Uncomplicated Skin and Skin Structure Infections: 250-500 mg twice daily for 10 days.
  • Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
  • Uncomplicated Gonorrhoea: 1000 mg twice daily as a single dose.
  • Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
  • MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
  • Early Lyme Disease: 500 mg twice daily for 20 days.
• Pediatric Patients (3 months to 12 years):
  • Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days.
  • Acute Otitis Media: 30 mg/kg/day twice daily for 10 days.
  • Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day twice daily for 10 days.
  • Impetigo: 30 mg/kg/day twice daily for 10 days.

Cefuroxime-Clavulanic Acid tablets can be taken regardless of food intake.
Use as directed by a registered healthcare provider.

Interactions

• Probenecid: When administered concurrently with Cefuroxime-Clavulanic Acid, probenecid increases the area under the serum concentration-time curve by 50%.
• Reduced gastric acidity: Medications that reduce gastric acidity may lower the bioavailability of Cefuroxime, thereby reducing its effect.

Contraindications
Cefuroxime-Clavulanic Acid should not be used in individuals with:

• Known allergy to cephalosporin antibiotics.
• A history of Pseudomembranous Colitis.

Side Effects
Cefuroxime-Clavulanic Acid is typically well tolerated. However, some individuals may experience:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, or abdominal discomfort.
• Rare side effects: Renal dysfunction, anaphylaxis, angioedema, pruritus, rash, or serum sickness-like urticaria (less than 0.2% of cases).

Pregnancy & Lactation

• Pregnancy: Cefuroxime-Clavulanic Acid should generally be avoided during the first trimester unless absolutely necessary. However, it can be safely used in later stages of pregnancy to treat urinary and other infections.
• Lactation: Cefuroxime-Clavulanic Acid is excreted in breast milk in small quantities. Although the risk of sensitizing the infant is low, use with caution during breastfeeding.

Precautions & Warnings

• Cefuroxime should be used cautiously in patients receiving potent diuretics or those with a history of colitis.

Therapeutic Class

• Second-generation Cephalosporins, Vaccines, Anti-sera & Immunoglobulins.

Storage Conditions

• Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of reach of children.

Common Questions about Clavurox 250 mg Tablet

What is Clavurox 250 mg Tablet?
Clavurox 250 mg Tablet combines Cefuroxime, a cephalosporin antibiotic, with Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat bacterial infections caused by sensitive organisms.

What is Clavurox 250 mg Tablet used for?
It is used to treat a variety of infections, including pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever, and early Lyme disease.

How long does it take for Clavurox 250 mg Tablet to take effect?
It starts working within 2-3 hours after administration.

How long do the effects of Clavurox 250 mg Tablet last?
The effects last for 4-8 hours on average.

Can I consume alcohol while taking Clavurox 250 mg Tablet?
The interaction with alcohol is not well-documented. Consult your doctor before consuming alcohol.

Is Clavurox 250 mg Tablet habit-forming?
No, there is no evidence to suggest that Clavurox 250 mg Tablet is habit-forming.

Can Clavurox 250 mg Tablet be taken during pregnancy?
Yes, Cefuroxime-Clavulanic Acid can be safely used during pregnancy with medical supervision.

Can Clavurox 250 mg Tablet be taken while breastfeeding?
Yes, it is safe to use while breastfeeding, as it enters breast milk at low levels.

Quick Tips

• Complete the full course of treatment as prescribed, even if you feel better. Stopping treatment early may allow the infection to return and become harder to treat.
• Take the medicine with food to minimize the risk of an upset stomach.
• Diarrhea is a common side effect; consider taking probiotics to help manage it. Consult your doctor if you notice bloody stools or severe abdominal cramps.
• If you experience an itchy rash, swelling of the face, throat, or tongue, or difficulty breathing, stop taking the medication and seek immediate medical attention.