Clavurox 500 mg+125 mg

Description

Indications
Clavurox is prescribed for the treatment of bacterial infections caused by susceptible microorganisms. It is effective in managing:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media: Due to Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis
• Acute Bacterial Exacerbation of Chronic Bronchitis
• Secondary Bacterial Infections of Acute Bronchitis
• Uncomplicated Skin and Skin Structure Infections
• Uncomplicated Urinary Tract Infections (UTIs)
• Uncomplicated Gonorrhea
• Community-Acquired Pneumonia
• Multidrug-Resistant (MDR) Typhoid Fever
• Early Lyme Disease

Pharmacology Clavurox combines two active ingredients: Cefuroxime and Clavulanic Acid.

• Cefuroxime is a second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, effectively killing susceptible Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains.
• Clavulanic Acid is a beta-lactamase inhibitor derived from Streptomyces clavuligerus. It binds irreversibly to beta-lactamase enzymes, preventing bacterial resistance and enhancing the efficacy of Cefuroxime against resistant bacterial strains.

Dosage & Administration Dosage should be determined by a healthcare provider. The recommended doses are:

For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days
• Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days
• Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days
• Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days
• Uncomplicated Skin and Soft Tissue Infections: 250-500 mg twice daily for 10 days
• Uncomplicated UTIs: 250 mg twice daily for 7-10 days
• Uncomplicated Gonorrhea: 1000 mg as a single dose
• Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days
• Early Lyme Disease: 500 mg twice daily for 20 days

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days
• Acute Otitis Media: 30 mg/kg/day in two divided doses for 10 days
• Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day in two divided doses for 10 days
• Impetigo: 30 mg/kg/day in two divided doses for 10 days

Clavurox tablets can be taken with or without food.

Drug Interactions

• Co-administration with probenecid increases Cefuroxime levels by 50%.
• Drugs reducing gastric acidity (e.g., antacids, proton pump inhibitors) may lower Cefuroxime absorption and effectiveness.

Contraindications

• Hypersensitivity to cephalosporins.
• History of Pseudomembranous Colitis.

Side Effects Clavurox is generally well tolerated. However, some possible side effects include:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal discomfort.
• Allergic reactions: Rash, pruritus, urticaria, angioedema, anaphylaxis (rarely <0.2%).
• Prolonged use may lead to overgrowth of resistant microorganisms.
• Rarely, renal dysfunction and serum sickness-like reactions may occur.

Pregnancy & Lactation

• While antibiotics should be avoided in the first trimester when possible, Clavurox can be safely used in later pregnancy for treating infections.
• Cefuroxime and Clavulanic Acid are excreted in breast milk in small amounts, but the risk of infant sensitization should be considered.

Precautions & Warnings

• Use with caution in patients receiving potent diuretics.
• Monitor patients with a history of colitis for gastrointestinal side effects.

Therapeutic Class

• Second-Generation Cephalosporins
• Vaccines, Anti-sera & Immunoglobulins

Storage Conditions

• Store in a cool, dry place below 30°C.
• Protect from light and moisture.
• Keep out of the reach of children.

Frequently Asked Questions

What is Clavurox used for? Clavurox is prescribed to treat bacterial infections such as tonsillitis, sinusitis, bronchitis, skin infections, urinary tract infections, gonorrhea, pneumonia, typhoid fever, and Lyme disease.

How quickly does Clavurox work? The medicine starts acting within 2-3 hours of ingestion.

How long do the effects last? The drug remains active in the body for approximately 4-8 hours.

Can Clavurox be taken with alcohol? There is no known direct interaction, but it is advisable to consult a doctor before consuming alcohol while on this medication.

Is Clavurox habit-forming? No habit-forming tendencies have been reported.

Can Clavurox be taken during pregnancy? Yes, it is considered safe during pregnancy for treating bacterial infections. However, consultation with a doctor is advised before use.

Is Clavurox safe for breastfeeding mothers? Yes, but as it is excreted in breast milk in small amounts, medical advice should be sought before use.

Quick Tips for Taking Clavurox

• Take the full course of medication, even if you start feeling better, to prevent resistance.
• Preferably take with food to reduce stomach upset.
• If diarrhea occurs, consider taking probiotics and consult your doctor if symptoms persist.
• Seek immediate medical help if you develop a rash, swelling, or breathing difficulties.
• Do not use leftover medicine for future infections without consulting a doctor.