Clavusef 250 mg+62.5 mg

Description

Clavusef

Indications Clavusef is prescribed for the treatment of infections caused by susceptible bacteria, including:

• Pharyngitis/Tonsillitis: Caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media: Due to Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis: Caused by Streptococcus pneumoniae or Haemophilus influenzae.
• Acute Bacterial Exacerbation of Chronic Bronchitis.
• Community-Acquired Pneumonia.
• Uncomplicated Skin and Soft Tissue Infections.
• Uncomplicated Urinary Tract Infections.
• Uncomplicated Gonorrhea.
• Multi-Drug Resistant (MDR) Typhoid Fever.
• Early Lyme Disease.

Pharmacology Clavusef is a combination of two active components:

• Cefuroxime: A second-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains.
• Clavulanic Acid: A beta-lactamase inhibitor derived from Streptomyces clavuligerus. It binds irreversibly to beta-lactamase enzymes, preventing the breakdown of Cefuroxime and enhancing its efficacy against resistant bacteria.

Dosage & Administration

For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days.
• Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days.
• Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days.
• Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days.
• Uncomplicated Skin and Soft Tissue Infections: 250-500 mg twice daily for 10 days.
• Uncomplicated Urinary Tract Infections: 250 mg twice daily for 7-10 days.
• Uncomplicated Gonorrhea: A single 1000 mg dose.
• Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days.
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days.
• Early Lyme Disease: 500 mg twice daily for 20 days.

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days.
• Acute Otitis Media: 30 mg/kg/day in two divided doses for 10 days.
• Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day in two divided doses for 10 days.
• Impetigo: 30 mg/kg/day in two divided doses for 10 days.

Cefuroxime-Clavulanic Acid tablets can be taken with or without food.

Drug Interactions

• Concurrent administration with Probenecid increases the serum concentration of Cefuroxime.
• Drugs that reduce gastric acidity may lower Cefuroxime bioavailability and interfere with postprandial absorption.

Contraindications

• Patients with known hypersensitivity to cephalosporins.
• Patients with a history of pseudomembranous colitis.

Side Effects Clavusef is generally well tolerated, but some patients may experience:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal discomfort.
• Allergic reactions: Rash, pruritus, angioedema, anaphylaxis (rare).
• Prolonged use may lead to overgrowth of non-susceptible organisms.
• Rare occurrences of renal dysfunction and serum sickness-like urticaria.

Pregnancy & Lactation

• While antibiotics should be avoided in the first trimester, Cefuroxime-Clavulanic Acid can be used during later pregnancy if necessary.
• Small amounts of the drug are excreted into breast milk, so its use in breastfeeding mothers should be considered carefully.

Precautions & Warnings

• Use cautiously in patients with a history of colitis.
• Patients receiving potent diuretics should be monitored for renal function.

Therapeutic Class

• Second-generation cephalosporins.
• Anti-infective agents.
• Immunological therapies.

Storage Conditions

• Store below 30°C in a cool, dry place, away from light and moisture.
• Keep out of reach of children.

Common Questions about Clavusef 250 mg Tablet

What is Clavusef 250 mg Tablet? Clavusef is a combination of Cefuroxime (a cephalosporin antibiotic) and Clavulanic Acid (a beta-lactamase inhibitor) used to treat bacterial infections.

What infections does Clavusef 250 mg Tablet treat? Clavusef is effective against infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, pneumonia, typhoid fever, gonorrhea, urinary tract infections, and skin infections.

How long does it take for Clavusef to work? The medicine starts working within 2-3 hours after administration.

How long do its effects last? The effects typically last for 4-8 hours per dose.

Is it safe to consume alcohol while taking Clavusef? There is no known interaction, but it is best to consult a doctor before consuming alcohol while on this medication.

Is Clavusef habit-forming? No, Clavusef does not have habit-forming tendencies.

Can Clavusef be taken during pregnancy? It is considered safe for use in pregnancy when prescribed by a doctor.

Can Clavusef be used while breastfeeding? Yes, it is safe during breastfeeding, but consultation with a doctor is recommended.

Quick Tips for Taking Clavusef 250 mg Tablet

• Complete the full course of treatment even if you feel better to prevent resistance.
• Take it with food to avoid stomach upset.
• Diarrhea is a possible side effect—consult your doctor if symptoms are severe.
• Seek immediate medical attention if you develop allergic reactions such as rash, swelling, or breathing difficulties.
• Do not use leftover medication without a doctor’s advice.