Clavusef 500 mg+125 mg

Description

Indications
Clavusef 500 mg Tablet is used for the treatment of bacterial infections caused by susceptible organisms. It is effective in treating:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute bacterial otitis media, which may be caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase producing strains), or Streptococcus pyogenes.
• Acute bacterial exacerbations of chronic bronchitis.
• Acute bacterial maxillary sinusitis.
• Uncomplicated skin and soft tissue infections (SSTIs).
• Uncomplicated urinary tract infections (UTIs).
• Uncomplicated gonorrhea.
• Community-acquired pneumonia.
• Multidrug-resistant (MDR) Typhoid fever.
• Early Lyme disease.

Pharmacology
Clavusef 500 mg Tablet is a combination of two active ingredients: Cefuroxime and Clavulanic Acid.

• Cefuroxime is a second-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis. It is effective against a wide range of both Gram-positive and Gram-negative bacteria, including many beta-lactamase producing strains.

• Clavulanic Acid is a beta-lactamase inhibitor derived from Streptomyces clavuligerus. It binds irreversibly to beta-lactamase enzymes, preventing them from deactivating Cefuroxime. This allows Cefuroxime to maintain its antibacterial activity, even against beta-lactam-resistant bacteria.

Dosage and Administration

For Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days.
• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days.
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days.
• Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5–10 days.
• Uncomplicated skin and soft tissue infections: 250-500 mg twice daily for 10 days.
• Uncomplicated urinary tract infections: 250 mg twice daily for 7–10 days.
• Uncomplicated Gonorrhea: 1000 mg as a single dose.
• Community-acquired pneumonia: 250-500 mg twice daily for 5–10 days.
• MDR Typhoid Fever: 500 mg twice daily for 10–14 days.
• Early Lyme disease: 500 mg twice daily for 20 days.

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day divided into two doses for 5–10 days.
• Acute otitis media: 30 mg/kg/day divided into two doses for 10 days.
• Acute bacterial maxillary sinusitis: 30 mg/kg/day divided into two doses for 10 days.
• Impetigo: 30 mg/kg/day divided into two doses for 10 days.

Clavusef tablets can be taken with or without food.

Interactions

• Probenecid may increase the serum concentration of Cefuroxime by 50%.
• Medications that reduce gastric acidity may lower the bioavailability of Cefuroxime, potentially reducing its effectiveness.

Contraindications
Clavusef should not be used in patients with:

• Known hypersensitivity to cephalosporins.
• A history of Pseudomembranous Colitis.

Side Effects
Common side effects include:

• Nausea, vomiting, diarrhea, abdominal pain, or discomfort.
• As with other antibiotics, long-term use may lead to overgrowth of non-susceptible microorganisms.

Rare side effects (less than 0.2%) may include:

• Renal dysfunction, anaphylaxis, angioedema, pruritus, rash, and serum sickness-like urticaria.

Pregnancy & Lactation

• Cefuroxime-Clavulanic Acid combination can be used safely in pregnancy, particularly for treating urinary and other infections in later stages.
• It is excreted into breast milk in small amounts; therefore, nursing mothers should use caution.

Precautions & Warnings

• Use with caution in patients on diuretics or those with a history of colitis.
• If you experience any signs of allergic reactions such as a rash or difficulty breathing, stop using the medication and contact your doctor immediately.

Therapeutic Class

• Second-generation Cephalosporins, Anti-infective agents.

Storage Conditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Frequently Asked Questions about Clavusef 500 mg Tablet

What is Clavusef 500 mg Tablet?
Clavusef 500 mg Tablet is a combination of Cefuroxime, a cephalosporin antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat bacterial infections caused by susceptible organisms.

How does Clavusef 500 mg Tablet work?
Cefuroxime works by inhibiting bacterial cell wall synthesis, while Clavulanic Acid protects Cefuroxime from degradation by beta-lactamase enzymes produced by resistant bacteria.

Can Clavusef 500 mg Tablet be taken with food?
Yes, Clavusef 500 mg Tablet can be taken with or without food. However, it is recommended to take it with food to avoid stomach upset.

Is Clavusef 500 mg Tablet safe during pregnancy?
Yes, Clavusef 500 mg Tablet can be used during pregnancy to treat infections, but always consult your doctor before use.

Can Clavusef 500 mg Tablet be taken while breastfeeding?
Clavusef 500 mg Tablet is safe for use while breastfeeding. It enters the breast milk in small amounts, but risks to the infant are minimal.

Is alcohol safe to consume while taking Clavusef 500 mg Tablet?
The interaction between alcohol and Clavusef 500 mg Tablet is not well-documented. It is advisable to consult your doctor regarding alcohol consumption.

Is Clavusef 500 mg Tablet habit-forming?
No, Clavusef 500 mg Tablet does not have any habit-forming tendencies.

What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose. Do not double the dose to make up for a missed one.

Important Notes

• Always complete the full course of antibiotics as prescribed by your doctor, even if you feel better before the treatment is finished. Stopping early may cause the infection to return and become harder to treat.
• If you experience any severe side effects, such as difficulty breathing, swelling of the face, or a rash, stop the medication and seek immediate medical help.
• Do not use leftover medication for future infections. Always consult your doctor before using any antibiotics.