Clindacin Plus 1.2%+0.025%

Description

Indications

Clindamycin and Tretinoin Gel is indicated for the topical treatment of Acne vulgaris.

Note: Always use as advised by a registered healthcare professional.

Pharmacology

This gel combines Clindamycin phosphate, a lincosamide antibiotic, and Tretinoin, a retinoid.

• Clindamycin binds to the 50S ribosomal subunit in susceptible bacteria, inhibiting peptide chain elongation and preventing bacterial protein synthesis. This action suppresses the growth of Propionibacterium acnes, reducing acne occurrences.

• Tretinoin works by decreasing the cohesiveness of follicular epithelial cells and increasing cellular turnover, helping to bring comedones (pore blockages) to the surface, promoting clearer skin.

Dosage & Administration

Before bedtime:

1. Wash your face gently with mild soap and water.
2. Pat your skin dry.
3. Apply a thin layer of the gel to the affected area using your fingertips.

In the morning:

• Apply a sunscreen after using the gel to protect your skin from UV exposure.
• Do not wash your face more than 2-3 times a day.
• Reapply sunscreen as needed.

Note: The safety and effectiveness of this product in children under 12 years of age have not been established.

Drug Interactions

• Other Potentially Irritating Products: Use caution when combining Clindamycin and Tretinoin with other topical products that may irritate the skin, such as medicated or abrasive soaps, cosmetics with a strong drying effect, high-concentration alcohol-based products, astringents, or lime.

• With Erythromycin: The activity of both Clindamycin and Erythromycin can be decreased when used together, so it is not recommended to use them concurrently.

• With Neuromuscular Medications: The effectiveness of neuromuscular medications may be increased when used together with Clindamycin. Care should be taken during such combinations.

Contraindications

Clindamycin and Tretinoin Gel should not be used by individuals who are hypersensitive to Clindamycin, Tretinoin, or any other component of the gel.

Side Effects

Common side effects of Clindamycin and Tretinoin Gel may include:

• Erythema (redness of the skin)
• Scaling
• Nasopharyngitis (inflammation of the nasal passages)
• Dry skin
• Cough
• Sinusitis (sinus inflammation)
• Diarrhea

Pregnancy & Lactation

It is not known whether Clindamycin or Tretinoin are excreted in human milk. Special caution should be exercised when applying this gel to nursing mothers.

Precautions & Warnings

• Avoid contact with sensitive areas: Do not apply the gel to your eyes, nose, ears, lips, cuts, burns, or infected skin.

• Sunlight exposure: After applying the gel, avoid prolonged sun exposure or use appropriate sun protection to reduce the risk of sunburn.

Therapeutic Class

Topical antibiotic & retinoid preparations.

Storage Conditions

• Store below 25°C, away from light and moisture.
• Keep out of the reach of children.