Defrol 1000 IU

Description

Indications
Vitamin D3 deficiency may occur in individuals with limited sun exposure or those whose diet lacks sufficient Vitamin D3.
Vitamin D3 plays a crucial role in the absorption of calcium and phosphate, both of which are necessary for healthy bones and teeth, helping to prevent conditions such as rickets, osteomalacia, and osteoporosis.
It is also important during pregnancy and breastfeeding, as it is essential for the development of the growing infant and helps prevent pre-eclampsia.
Vitamin D3 also plays a vital role in strengthening the immune system.

Dosage & Administration
For Capsules (Adults):

• Treatment of Vitamin D3 deficiency: 40,000 IU once a week for 7 weeks. For maintenance therapy, doses range from 1,400 to 2,000 IU per day. To assess the target level of 25-hydroxyvitamin D, it should be measured 3-4 months after starting maintenance therapy.
• Prevention of Vitamin D3 deficiency: 20,000 IU every 4 weeks. Higher doses may be needed in certain circumstances.
• Adjunct to osteoporosis therapy: 20,000 IU once a month.

For Capsules (Children aged 12-18 years):

• Treatment of Vitamin D3 deficiency: 20,000 IU once every 2 weeks for 6 weeks.
• Prevention of Vitamin D3 deficiency: 20,000 IU every 6 weeks.

For Film-Coated Tablets:

• 1,000 IU (1-2 tablets) daily, or as directed by a physician. It is recommended to take the medicine with food or within 1 hour after eating.

For Oroflash or Chewable Tablets:

• 1,000 IU to 2,000 IU daily, or as directed by a physician. Take the medicine with food or within 1 hour after a meal. Chew the tablet before swallowing.

For Syrup:

• For patients at risk of Cholecalciferol deficiency:
  • 0-1 year: 400 IU/day (2 ml)

  • 1 year: 600 IU/day (3 ml)

• For patients with Cholecalciferol deficiency:
  • 0-1 year: 2,000 IU/day (+50,000 IU/week) for 6 weeks
  • 1-18 years: 2,000 IU/day for 6 weeks

For Injection:

• Prevention:
  • Infants receiving Vitamin D-enriched milk: ½ ampoule (0.5 ml) = 100,000 IU every 6 months.
  • Nursed infants or infants not receiving Vitamin D-enriched milk, or young children up to 5 years: 1 ampoule (1 ml) = 200,000 IU every 6 months.
  • Adolescents: 1 ampoule (1 ml) = 200,000 IU every 6 months during winter.
  • Pregnancy: ½ ampoule (0.5 ml) = 100,000 IU from the 6th or 7th month of pregnancy.
  • Elderly: ½ ampoule (0.5 ml) = 100,000 IU every 3 months.
  • For digestive disorders, antiepileptic treatments, or other specific conditions: ½ ampoule (0.5 ml) = 100,000 IU or 1 ampoule (1 ml) = 200,000 IU every 3 or 6 months.
• For Vitamin D deficiency:
  • 1 ampoule (1 ml) = 200,000 IU, which can be repeated every 1 to 6 months, or as directed by a healthcare professional.

Interaction
Several medications can cause Vitamin D3 deficiencies by interfering with its absorption and metabolism. These include magnesium-containing antacids, digoxin, thiazide diuretics, cholestyramine, cholestipol, phenytoin, phenobarbital, orlistat, and mineral oil. Additionally, corticosteroids such as prednisolone may increase the need for Vitamin D3.

Contraindications
Vitamin D3 should not be used in conditions associated with hypercalcemia. It is also contraindicated for individuals with a known hypersensitivity to Vitamin D3 or any of its components. It should not be used if there is evidence of Vitamin D3 toxicity.

Side Effects
Side effects are rare but may include anorexia, fatigue, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, dizziness, and increased levels of calcium and phosphate in the blood and urine.

Pregnancy & Lactation
Studies indicate that doses up to 4,000 IU of Vitamin D3 are safe during pregnancy. The recommended daily intake for pregnant women is 400 IU; however, those with Vitamin D3 deficiency may require higher doses. Pregnant women should follow their healthcare provider’s guidance as their needs may vary based on their condition and response to treatment.
Vitamin D3 and its metabolites are excreted in breast milk. There have been no reported cases of overdose in infants due to maternal use of Vitamin D3; however, if additional Vitamin D3 is prescribed to a breastfeeding infant, the total dose, including any supplemental vitamin D3 given to the mother, should be considered.

Precautions & Warnings
Plasma calcium levels should be monitored regularly in patients receiving high doses of Vitamin D3, as well as in individuals with renal impairment, and during pregnancy and lactation. Patients using digoxin or thiazide diuretics should consult a healthcare provider before using Vitamin D3 supplements. Those with liver or kidney disease, primary hyperthyroidism, lymphoma, tuberculosis, or granulomatous disease should seek medical advice before supplementing with Vitamin D3.

Use in Special Populations
The safety and efficacy of Vitamin D3 in children under 12 years have not been established.

Overdose Effects
Excessive intake of Vitamin D3 may lead to hypervitaminosis D.

Therapeutic Class
Vitamin in bone formation, Vitamin D preparations

Storage Conditions
Store below 30ºC, away from light and moisture. Keep out of reach of children.