Dexit 0.5 mg+10 mg

Description

Indications:

Flupentixol and Melitracen tablet is commonly prescribed for the management of various mental health conditions, including:

• Anxiety
• Depression
• Apathy
• Psychogenic depression
• Depressive neuroses
• Masked depression
• Psychosomatic disorders with anxiety and apathy
• Menopausal depression
• Dysphoria and depression associated with alcohol and drug dependence

Please use this medication only as directed by a registered healthcare provider.

Pharmacology:

Flupentixol and Melitracen combine two well-established pharmacological agents. Flupentixol, a neuroleptic, provides both anxiolytic (anxiety-reducing) and antidepressant effects when administered in low doses. Melitracen, a bipolar thymoleptic, exhibits activating properties at lower doses. Together, these compounds offer a therapeutic combination that is effective in treating depression, anxiety, and related conditions.

• After oral administration, flupentixol reaches its peak serum concentration in approximately 4 hours, and melitracen follows the same timeframe.
• The biological half-life of flupentixol is approximately 35 hours, while melitracen’s half-life is around 19 hours.
• The combination of flupentixol and melitracen does not appear to affect the individual pharmacokinetics of each compound.

Dosage & Administration:

• Adults: The standard starting dose is 2 tablets daily, typically taken in the morning and noon. In cases of severe symptoms, the morning dose may be increased to 2 tablets.
• Elderly Patients: The recommended starting dose is 1 tablet in the morning.
• Maintenance Dose: The usual maintenance dose is 1 tablet daily, typically taken in the morning. For those experiencing insomnia or significant restlessness, additional treatment with a sedative may be considered during the acute phase.

Always consult your healthcare provider for the appropriate dosage based on your condition.

Interactions:

• Enhanced Effects: This tablet may amplify the effects of alcohol, barbiturates, and other central nervous system (CNS) depressants.
• Contraindicated Combinations: Avoid combining this medication with MAO inhibitors, as it could lead to hypertensive crises.
• Reduced Effects: The antihypertensive effect of guanethidine and similar medications may be reduced by this drug combination. Additionally, melitracen can enhance the effects of adrenaline and noradrenaline.

Contraindications:

Flupentixol and Melitracen should not be used in the following situations:

• During the immediate recovery phase following a myocardial infarction (heart attack)
• In individuals with defects in bundle-branch conduction
• Those with untreated narrow-angle glaucoma
• In cases of acute intoxication from alcohol, barbiturates, or opiates
• Patients who have taken an MAO inhibitor within the past two weeks
• Not recommended for excitable or overactive individuals, as the activating effects may exacerbate these conditions.

Side Effects:

Generally, side effects are rare when taken as prescribed. However, some individuals may experience:

• Transient restlessness
• Insomnia

If any unusual or severe side effects occur, contact your healthcare provider immediately.

Pregnancy & Lactation:

This medication should preferably be avoided during pregnancy and breastfeeding. Always consult your doctor before using any medication during these times.

Precautions & Warnings:

• If you have previously been treated with sedative tranquilizers, it is recommended that these be gradually withdrawn under a healthcare professional’s supervision.
• Use with caution in elderly patients or those with pre-existing medical conditions.

Overdose Effects:

In the event of an overdose, symptoms may primarily involve anticholinergic effects from melitracen, with rarer extrapyramidal symptoms from flupentixol. Immediate medical attention should be sought. Gastric lavage and activated charcoal may be administered. Supportive measures for respiratory and cardiovascular systems should be initiated, and seizure activity can be treated with diazepam. Extrapyramidal symptoms can be managed with biperiden.

Do not use epinephrine (adrenaline) in overdose situations.

Therapeutic Class:

Combined anxiolytics and antidepressant medications

Storage Conditions:

Store this medication in a cool, dry place away from light, at temperatures not exceeding 30°C. Keep out of reach of children and do not use beyond the expiration date. Dispose of any unused medications properly by asking your pharmacist for guidance to protect the environment.

Common Questions about Dexit 0.5 mg Tablet:

• What is Dexit 0.5 mg Tablet?
  Dexit 0.5 mg Tablet contains Flupentixol and Melitracen and is used to treat anxiety, depression, apathy, psychogenic depression, depressive neuroses, and other related conditions.
• Can I take Dexit 0.5 mg Tablet without eating?
  It is advisable to follow the dosing schedule as prescribed by your doctor. If you miss a meal, consult with your healthcare provider for guidance on adjusting your dose.
• What if I miss a dose?
  Take the missed dose as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses to make up for a missed dose.
• How long do the effects last?
  The effects of Dexit 0.5 mg Tablet generally last for about 24 hours.
• Is it safe to take Dexit 0.5 mg Tablet during pregnancy?
  This medication is not recommended during pregnancy. Always consult your doctor before taking any medication during pregnancy or lactation.

Quick Tips:

• Dexit 0.5 mg Tablet is effective in treating anxiety and depression.
• It may cause dizziness or sleepiness, so use caution while performing tasks that require focus, such as driving.
• Avoid alcohol as it can exacerbate the drowsiness caused by Dexit 0.5 mg Tablet.
• Monitor your blood sugar levels regularly, as the medication may cause changes in glucose levels.
• Inform your doctor about any liver, thyroid, or heart disorders before starting the medication.
• If you experience mood changes or suicidal thoughts, consult your doctor immediately.
• Let your healthcare provider know if you are taking Dexit 0.5 mg Tablet before any surgical procedures.