Diamicron MR 30 mg

Indications
Diamicron MR is an oral antidiabetic medication that belongs to the sulphonylurea group, used to lower blood sugar levels in individuals with type 2 diabetes mellitus. It is prescribed when diet, exercise, and weight loss alone are insufficient to control blood sugar levels. It is essential to follow a registered physician’s advice when taking this medication.

Pharmacology
Gliclazide, the active ingredient in Diamicron MR, is a second-generation sulfonylurea that helps to lower blood sugar by stimulating insulin release from the pancreas. It enhances calcium ion transport across pancreatic β-cell membranes and reduces glucose production by the liver.

Dosage & Administration

• Film-coated tablet: The initial dose for adults is generally 40 to 80 mg daily, which may be increased up to 320 mg daily in divided doses as needed. The tablet should be taken before meals.
• Modified release preparation: Always take Diamicron MR exactly as prescribed by your doctor or pharmacist. The dose will depend on your blood sugar levels, and factors such as weight loss, lifestyle changes, and stress may require dose adjustments. The recommended dose is 1 to 4 tablets (maximum 120 mg), taken as a single dose at breakfast. Swallow the tablets whole with a glass of water and do not chew or crush them. A meal should always follow the intake of the medicine.

Combination therapy with other medications like metformin, alpha-glucosidase inhibitors, thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, or insulin should be monitored by your doctor for proper dosage. If your blood sugar remains high despite following the prescribed dosage, contact your healthcare provider.

Overdose
In case of overdose, seek immediate medical attention. Symptoms of an overdose include low blood sugar (hypoglycaemia). This can be treated with sugar (4-6 lumps) or sugary drinks, followed by a substantial meal or snack. If unconscious, do not administer food or drink and call for emergency help immediately.

Missed Dose
If you miss a dose of Diamicron MR, take it at the usual time of your next dose. Do not take two doses at once to compensate for a missed dose.

Stopping Treatment
As diabetes treatment is usually lifelong, consult your doctor before stopping Diamicron MR, as discontinuing the medication may cause high blood sugar (hyperglycaemia) and increase the risk of diabetes complications.

Interactions
Certain medications can either enhance or reduce the blood sugar-lowering effects of Diamicron MR. It may interact with:

• Other antidiabetic drugs, antibiotics (like sulphonamides), heart or blood pressure medications (beta-blockers, ACE inhibitors), antifungal treatments, and certain pain relievers (ibuprofen).
• Medicines that can reduce its effect include those used for central nervous system disorders, corticosteroids, and some asthma medications.
• Diamicron MR may increase the effects of anticoagulants like warfarin.

Alcohol
Alcohol consumption is not recommended, as it can unpredictably affect blood sugar control.

Driving and Operating Machinery
Low or high blood sugar levels can impair your ability to concentrate and react, which may be dangerous while driving or operating machinery. Consult your doctor if you have frequent low blood sugar episodes or limited warning symptoms.

Contraindications
Do not use Diamicron MR if you are allergic to gliclazide or any other sulfonylureas, if you have insulin-dependent diabetes (type 1), diabetic ketoacidosis, severe kidney or liver disease, or if you are breastfeeding.

Side Effects
Common side effects include low blood sugar (hypoglycaemia), which can progress to drowsiness, loss of consciousness, or even coma if untreated. Rare side effects may include liver dysfunction, skin reactions like rash, hives, or angioedema, and blood disorders like low platelet count.

Pregnancy & Lactation
Gliclazide is not recommended during pregnancy. It is also contraindicated during breastfeeding. Always consult your doctor for advice before taking this medication.

Precautions & Warnings
Before starting treatment with Diamicron MR, ensure that you follow the prescribed plan that includes proper diet, exercise, and weight management. Regular monitoring of blood sugar levels is necessary. Be aware that certain conditions like fasting, skipping meals, or increasing physical activity can increase the risk of hypoglycaemia.

If you have a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency, consult your doctor as this may cause hemolytic anemia. Diamicron MR is not recommended for children due to insufficient data.

Therapeutic Class
Sulfonylureas

Storage Conditions
Store Diamicron MR below 30°C and keep it out of the reach of children. Do not use the medicine past its expiry date. Dispose of unused medication properly to protect the environment.

Chemical Structure
Molecular Formula: C15H21N3O3S

Common Questions

1. What is Diamicron MR 30 mg Tablet?
   Diamicron MR 30 mg Tablet is used to manage type 2 diabetes by stimulating the pancreas to release more insulin and improving the body’s ability to utilize existing insulin.
2. What happens if I take Diamicron MR 30 mg Tablet without eating?
   Do not take this medication without food, as the dosage is linked to meal times.
3. What if I miss a dose?
   If you miss a dose, take it when you remember unless it’s nearly time for the next dose. Avoid taking two doses to make up for the missed one.
4. How long does Diamicron MR 30 mg Tablet last?
   The effects typically last 24 hours.
5. Is it safe to use Diamicron MR during pregnancy?
   No, Diamicron MR is not recommended during pregnancy.

General Instructions
Always follow your doctor’s instructions for dosage and timing, and monitor your blood sugar regularly. Carry sugary snacks in case of hypoglycaemia.

Consult a registered physician for advice on medication use.

Packaging
Diamicron MR 30 mg Tablet is available in packs of 30 tablets.