Doximar Tablet 400 mg

Description

Indications
Doximar is used to treat the following conditions:

• Bronchial asthma
• Bronchospasm
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary disease with a spastic bronchial component

Use this medication only as prescribed by a registered physician.

Pharmacology
Doxophylline is a novel bronchodilator. It differs structurally from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase 4, which relaxes bronchial smooth muscle. Unlike Theophylline, Doxophylline has a decreased affinity for adenosine A1 and A2 receptors, contributing to its better safety profile. It is also known to inhibit platelet-activating factor (PAF) and the generation of leukotriene production.

Dosage & Administration

• Elderly: Take 200 mg tablet two or three times daily.
• Adults: Take 400 mg tablet two or three times daily or as prescribed by the physician.
• Children:
  • Over 12 years of age: Take 10 ml syrup or 200 mg tablet two or three times daily.
  • 6-12 years of age: Take 6-9 mg/kg body weight twice daily (e.g., for a child weighing 10 kg, give 3 ml (60 mg) twice daily).
    If a daily dose of 400 mg is required, the Doxophylline SR tablet should be taken once daily or as prescribed by the physician.

Use this medication only as prescribed by a registered physician.

Interaction
Doximar should not be administered with other xanthine preparations. Limit consumption of caffeine-containing foods and beverages. Caution should be used when administering Doximar with ephedrine or other sympathomimetic drugs. Many drugs, including erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol, may reduce the hepatic clearance of xanthine derivatives, leading to increased plasma levels. Conversely, drugs like phenytoin, other anticonvulsants, and cigarette smoking may increase the clearance of xanthine derivatives, reducing plasma half-life. In these cases, dosage adjustments may be necessary.

Contraindications
Doxophylline is contraindicated in individuals with hypersensitivity to the drug or other xanthine derivatives. It is also contraindicated in patients with acute myocardial infarction, hypotension, and during lactation.

Side Effects
Patients may experience nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, extrasystoles, tachypnea, and, in rare cases, hyperglycemia or albuminuria. In the case of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur. These symptoms may represent signs of intoxication, and the treatment should be discontinued. If necessary, treatment may be resumed at lower doses after all signs and symptoms of toxicity have subsided.

Pregnancy & Lactation
Animal studies have shown that Doxophylline does not affect pre- and postnatal growth. However, due to insufficient clinical evidence regarding its effects during pregnancy, the use of this medication should be carefully considered based on the risk-benefit ratio. Doxophylline is contraindicated during lactation.
The product does not affect alertness, so it does not interfere with driving or operating machines.

Precautions & Warnings
Several factors can reduce hepatic clearance of xanthine derivatives, increasing plasma levels. These include age, congestive cardiac decompensation, COPD, severe liver disease, infections, and the concurrent use of drugs like erythromycin, TAO, and others. In such cases, dosage reductions may be required, and monitoring of drug levels is advised.

Use caution in patients with cardiac disease, hypertension, the elderly, severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcers, and renal impairment. Special care should be taken in patients with congestive heart failure, as the drug may remain in the system longer, even after treatment is discontinued. There is no risk of addiction or dependence.

Overdose Effects
In case of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur, which may be signs of intoxication. As there is no specific antidote, symptomatic treatment for cardiovascular collapse should be initiated. After the resolution of toxicity symptoms, the medication may be resumed at lower doses as per the physician’s discretion.

Therapeutic Class
Bronchodilator, Methyl xanthine derivatives

Storage Conditions
Store in a dry place, away from light and heat. Keep out of reach of children. Doximar should be used only on prescription from a specialist physician.