This medication is used for symptomatic relief from hyperacidity associated with conditions such as peptic ulcers, gastritis, peptic esophagitis, gastric hyperacidity, heartburn, sour stomach, and hiatus hernia. It is also effective in preventing stress ulceration and gastrointestinal (GI) bleeding. Additionally, it acts as an antiflatulent, helping to alleviate symptoms of gas, including post-operative gas pain. It provides rapid relief from acid-related discomfort, disperses gastric foam, and facilitates the expulsion of gas and air.

Composition Each tablet contains:

Dried Aluminium Hydroxide Gel BP (Al2O3, 47% minimum): 425.53 mg
Magnesium Hydroxide BP: 400 mg
Simethicone USP: 30 mg

Each 5 ml of suspension contains:

Aluminium Oxide (Equivalent to Aluminium Hydroxide Gel USP): 200 mg
Magnesium Hydroxide (Equivalent to Magnesium Hydroxide Paste USP): 400 mg
Simethicone USP: 30 mg

Pharmacology This formulation consists of non-systemic acid-neutralizing agents combined with an antiflatulent. It provides long-lasting and reliable relief. Aluminium Hydroxide and Magnesium Hydroxide help alleviate ulcers by neutralizing gastric acid secreted by the stomach’s parietal cells. Simethicone works as an antifoaming agent, reducing surface tension and causing gas bubbles to collapse. This facilitates the elimination of gas from the GI tract, helping to relieve bloating and discomfort.

Simethicone is physiologically inert, meaning it does not interfere with gastric secretion or nutrient absorption. It is not absorbed into the body and is excreted unchanged in the feces.

Dosage & Administration

Tablets: 1-2 tablets taken 1-3 hours after meals and at bedtime, or as prescribed by a physician.
Suspension: 1-2 teaspoonfuls taken 1-3 hours after meals and at bedtime, or as directed by a physician.

Interaction Antacids may alter the absorption of other oral medications. They may decrease the bioavailability of certain drugs, including theophylline, tetracyclines, quinolone antibiotics, isoniazid, ketoconazole, ethambutol, some antimuscarinic drugs, benzodiazepines, phenothiazines, ranitidine, indomethacin, nitrofurantoin, fluoride, phosphate, propranolol, atenolol, digoxin, and various vitamins. Conversely, antacids can increase the bioavailability of medications such as sulfonamides, levodopa, valproic acid, and enteric-coated aspirin.

Contraindications This medication should not be used by individuals with renal failure, hypophosphatemia, severe debilitation, alkalosis, or hypermagnesemia. It is also contraindicated when abdominal distension may indicate partial or complete intestinal obstruction.

Side Effects Gastrointestinal side effects are uncommon. However, excessive consumption may lead to diarrhea, constipation, or regurgitation.

Pregnancy & Lactation The use of antacids should be avoided during the first trimester of pregnancy unless specifically directed by a physician.

Precautions & Warnings This medication should be used with caution in individuals with kidney disease.

Therapeutic Class Antacids

Storage Conditions Store below 30°C, away from light and moisture. Keep out of reach of children.