Hepaximin 550 mg

Description

Here’s a rewritten version of the Hepaximin product description:

Indications
Hepaximin is prescribed for the following conditions:

• Treatment of traveler’s diarrhea caused by non-invasive strains of E. coli
• Reducing the risk of overt hepatic encephalopathy
• Managing bacterial overgrowth in patients with irritable bowel syndrome

Use this medication only as directed by a registered healthcare professional.

Pharmacology
Rifaximin, the active ingredient in Hepaximin, is a semisynthetic, rifamycin-based antibiotic that acts locally in the gastrointestinal tract. Unlike other orally administered antibiotics, very little of the drug is absorbed into the bloodstream. Rifaximin works by inhibiting bacterial RNA synthesis, specifically targeting the beta-subunit of DNA-dependent RNA polymerase. This results in a bactericidal effect against a wide range of both Gram-positive and Gram-negative, as well as aerobic and anaerobic bacteria.

Dosage & Administration

• Traveler’s Diarrhea: For patients aged 12 years and older, take 200 mg three times a day for 3 days.
• Hepatic Encephalopathy: For patients aged 18 years and older, take 550 mg twice daily.
• Bacterial Overgrowth in Irritable Bowel Syndrome: Take 400 mg three times a day for 10 days or 550 mg three times a day for 14 days. This medication can be taken with or without food.

Use this medication only as directed by a registered healthcare professional.

Interactions
In vitro studies suggest that Hepaximin may induce the CYP3A4 enzyme. However, in patients with normal liver function, the recommended dose of Hepaximin is not expected to significantly induce CYP3A4.

Contraindications
Hepaximin is contraindicated in patients who have a known hypersensitivity to Rifaximin, any other rifamycin-class antibiotics, or any other component of this product.

Side Effects
Common side effects of Hepaximin may include flatulence, headache, abdominal pain, rectal tenesmus (feeling of incomplete bowel evacuation), urgency to defecate, nausea, constipation, fever, and vomiting. Severe allergic reactions, including anaphylaxis, angioneurotic edema, and exfoliative dermatitis, have been reported.

Pregnancy & Lactation
Hepaximin is classified as Pregnancy Category C. It is not known whether Rifaximin is excreted in human milk. Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Precautions & Warnings

• Hepaximin is not effective in treating diarrhea complicated by fever or blood in the stools. If symptoms worsen or persist for more than 24–48 hours, discontinue use and consider alternative antibiotic therapy.
• Pseudomembranous colitis, a serious colon infection, has been reported with many antibiotics, and it can range from mild to life-threatening. If diarrhea occurs after taking this medication, consider the possibility of pseudomembranous colitis.
• Use in Special Populations
  • Renal Impairment: The effects of Hepaximin in patients with renal impairment have not been fully studied.
  • Hepatic Impairment: In patients with liver impairment, systemic exposure to Hepaximin is significantly higher compared to healthy individuals.

Overdose Effects
There is no specific treatment for Hepaximin overdose. In case of overdose, stop the medication and provide symptomatic treatment along with supportive care as needed.

Therapeutic Class
4-Quinolone preparations

Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.