Risedon 150 mg

Description

Indications:
Risedon belongs to a class of medications called bisphosphonates. It works by altering the bone remodeling process, slowing bone loss, and increasing bone mass, which helps prevent fractures. Risedon is prescribed for:

• Preventing and treating osteoporosis in postmenopausal women.
• Increasing bone mass in men with osteoporosis.
• Preventing and treating osteoporosis caused by long-term steroid use (e.g., prednisone).
• Treating Paget’s disease of bone in men and women.

Always consult a registered physician before use.

Pharmacology:
Bone is constantly being broken down and rebuilt. In osteoporosis, bone breakdown outpaces formation, leading to thinner, fragile bones and a higher risk of fractures, especially in the spine, hips, and wrists. Risedon binds to hydroxyapatite crystals in bones, inhibiting osteoclast activity and reducing bone resorption.

Dosage:

• Postmenopausal Osteoporosis (to reduce vertebral fractures):
  • 5 mg once daily, 35 mg once weekly, or 150 mg once monthly.
• Postmenopausal Osteoporosis (to reduce hip fractures):
  • 5 mg once daily or 35 mg once weekly.
• Prevention of Osteoporosis in Postmenopausal Women:
  • 5 mg once daily.
• Osteoporosis Due to Steroid Use:
  • 5 mg once daily.
• Osteoporosis in Men at High Risk of Fractures:
  • 35 mg once weekly.

Take the tablet on the same day each week or month as prescribed.

Administration:

• Take Risedon on an empty stomach, at least 30 minutes before the first food, drink (other than water), or medication of the day.
• If taking between meals, wait at least 2 hours before and after eating.
• If taking in the evening, wait at least 2 hours after the last meal.
• Swallow the tablet whole with a full glass of water (120 ml or more) while sitting or standing upright. Do not lie down for 30 minutes after taking the tablet.
• If a dose is missed:
  • 5 mg tablet: Take as soon as remembered, following the instructions above.
  • 35 mg tablet: Take one tablet the morning after remembering, then resume the weekly schedule. Do not take two tablets in one day.
  • 150 mg tablet: Take the missed tablet the morning after remembering if the next monthly dose is more than 7 days away.

Supplemental calcium and vitamin D are recommended if dietary intake is insufficient.

Interactions:

• Avoid taking antacids, supplements, or medications containing aluminum, calcium, magnesium, or other minerals within 30 minutes of Risedon, as they can interfere with absorption.
• Inform your doctor if you are taking aspirin, NSAIDs, or other medications.

Contraindications:

• Hypersensitivity to Risedon or its components.
• Hypocalcemia (low blood calcium levels).
• Severe renal impairment (creatinine clearance <30 ml/min).
• Pregnancy or lactation.

Side Effects:

• Serious Side Effects: Chest pain, difficulty swallowing, severe heartburn, jaw pain or swelling, severe joint or muscle pain.
• Common Side Effects: Mild heartburn, stomach upset, diarrhea, constipation, gas, headache, or mild joint/back pain.

Pregnancy and Lactation:

• Risedon is intended for postmenopausal women and should not be used during pregnancy or breastfeeding. If accidentally taken, stop immediately and consult a doctor.

Precautions and Warnings:

• Ensure adequate calcium and vitamin D intake.
• Do not lie down for 30 minutes after taking Risedon to avoid esophageal irritation.
• Use caution if you have kidney problems or cannot sit/stand upright for 30 minutes.
• Discontinue use and seek medical attention if you experience allergic reactions (e.g., swelling, difficulty breathing, rash).

Use in Special Populations:

• Pediatric Use: Safety and efficacy have not been established in children.
• Elderly Use: No dosage adjustment is needed.
• Renal Impairment: Contraindicated in severe renal impairment (creatinine clearance <30 ml/min).

Overdose:

• Symptoms may include hypocalcemia. Provide milk or antacids to bind Risedon and reduce absorption. Gastric lavage may be considered in severe cases.

Therapeutic Class:
Bisphosphonate preparations.

Storage Conditions:
Store in a cool, dry place, away from light and moisture. Keep out of children’s reach.