Risedon Plus 35 mg+500 mg

Description

Indications

• Helps prevent and manage osteoporosis in postmenopausal women.
• Supports bone mass improvement in men with osteoporosis.
• Addresses osteoporosis caused by prolonged use of steroid medications like prednisolone.
• Aids in the treatment of Paget’s disease in both men and women.
  Use only as directed by a registered physician.

Pharmacology

Bone tissue undergoes continuous remodeling, with old bone breaking down and new bone forming. Osteoporosis occurs when bone loss outpaces new bone formation, leading to fragile bones prone to fractures—especially in the spine, hips, and wrists. Postmenopausal women are at a higher risk due to hormonal changes.

Risedronate binds to hydroxyapatite crystals in bones, working as an antiresorptive agent. It inhibits osteoclast activity, reducing excessive bone breakdown while allowing bone formation to continue. Additionally, calcium plays a crucial role in regulating parathyroid hormone (PTH) levels, minimizing bone turnover and reducing fracture risk.

Dosage & Administration

This combination pack contains:

• Risedronate Sodium 35 mg (1 tablet) – Taken once a week.
• Calcium Carbonate 500 mg (6 tablets) – Taken daily for the remaining six days.

Administration Guidelines:

• Follow your healthcare provider’s instructions precisely.
• Take the Risedronate tablet in the morning before consuming any food or drink (except plain water).
• Remain seated or standing while taking the tablet.
• Swallow the tablet whole with a full glass of plain water. Do not chew, crush, or let it dissolve in your mouth.
• After taking the tablet, wait at least 30 minutes before lying down, eating, drinking (except water), or taking calcium, vitamins, or antacids.
• Continue using the medication for as long as prescribed by your doctor.

Recommended Schedule:

• Day 1 – Take one Risedronate Sodium tablet.
• Days 2 to 7 – Take one Calcium Carbonate tablet daily with food.

Use only as directed by a registered physician.

Drug Interactions

Inform your doctor about any medications you are currently using, including over-the-counter drugs. Specifically, avoid taking antacids, supplements, or medications containing aluminum, calcium, or magnesium within 30 minutes of Risedronate, as they may affect its absorption.

Possible Side Effects

• Common: Mild heartburn, stomach upset, diarrhea, gas, constipation, headache, joint or back pain.
• Serious (Seek medical attention if experienced): Chest pain, swallowing difficulties, worsening heartburn, severe bone/joint/muscle pain, jaw pain, numbness, or swelling.

Use During Pregnancy & Breastfeeding

• Not recommended during pregnancy. If taken accidentally, discontinue use and consult a doctor.
• Breastfeeding women should avoid this medication. If ingested unintentionally, stop usage immediately and seek medical advice.

Precautions & Warnings

Use with caution if you:

• Have low blood calcium levels (hypocalcemia).
• Cannot sit or stand for at least 30 minutes after taking the medication.
• Have impaired kidney function.
• Are allergic to Risedronate Sodium.
• Are pregnant, planning to conceive, or breastfeeding.

Special Populations

• Patients with severe kidney impairment (creatinine clearance <30 ml/min): Risedronate is not recommended.
• Elderly patients or those with mild kidney impairment: No dosage adjustment is required.

Therapeutic Class

Bisphosphonate Medications

Storage Instructions

Store in a cool, dry place, away from light and moisture. Keep out of reach of children.