Supotaria 50 mcg

Description

Interaction

• No specific studies have been conducted on the co-administration of this inhalation capsule with other inhaled anticholinergic drugs; therefore, such use is not recommended.
• This inhalation capsule has been used with other common COPD treatments, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids, without clinical evidence of drug interactions.
• Co-administration with indacaterol (a β2-adrenergic agonist) under steady-state conditions does not alter the pharmacokinetics of either drug.

Contraindications
This inhalation capsule is contraindicated in patients with:

• Hypersensitivity to glycopyrronium or any excipients in the formulation.

Side Effects
Common side effects:

• Dry mouth, cough, nasopharyngitis, vomiting, musculoskeletal pain, neck pain, diabetes mellitus, gastroenteritis, insomnia.

Less common side effects:

• Paradoxical bronchospasm, dysphonia, angioedema, hypersensitivity, pruritus, sinus congestion, throat irritation.

In elderly patients (above 75 years):

• Higher incidence of urinary tract infections and headaches.

Pregnancy & Lactation

• Pregnancy: There are no well-controlled studies on the use of this inhalation capsule in pregnant women with COPD. It should only be used if the potential benefit justifies the possible risk to the fetus.
• Lactation: It is unknown whether Glycopyrronium Bromide or its metabolites are excreted in human milk. Use in breastfeeding women should be considered with caution, weighing the benefits against potential risks to the infant.
• Fertility: Animal studies do not indicate any fertility concerns for males or females.

Precautions & Warnings

• This inhalation capsule is a long-term maintenance therapy and not for acute bronchospasm relief.
• Not suitable for patients under 18 years of age.
• Use with caution in patients with:
  • Narrow-angle glaucoma
  • Urinary retention
• If allergic reactions occur, such as angioedema (swelling of the face, tongue, lips, or difficulty breathing), hives, or skin rash, discontinue use immediately and seek alternative treatment.
• Paradoxical bronchospasm may occur, which can be life-threatening. If this happens, discontinue use and initiate alternative therapy.
• In patients with severe renal impairment (eGFR <30 mL/min/1.73m²) or end-stage renal disease requiring dialysis, this inhalation capsule should only be used if the benefits outweigh the potential risks.

Overdose Effects

• High doses may cause anticholinergic symptoms, requiring symptomatic treatment.
• In COPD patients, repeated administration of 100-200 mcg daily for 28 days has been well tolerated.
• Accidental oral ingestion of Glycare capsules is unlikely to cause acute toxicity.

Therapeutic Class

• Bronchodilator

Storage Conditions

• Do not swallow this capsule—use only with the designated inhalation device.
• Insert the Easycap into the Easyhaler for best performance.
• Remove the capsule from the blister immediately before use, as exposure to moisture may affect integrity.
• Store at a temperature below 30°C in a dry place, protected from light and moisture.