Ventofil Tablet 200 mg

Description

Indications
Ventofil is used for the treatment of:

• Bronchial asthma
• Bronchospasm
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary diseases with a spastic bronchial component

Use this medication only as directed by a registered physician.

Pharmacology
Ventofil contains Doxophylline, a novel bronchodilator that differs from Theophylline due to the presence of a dioxolane group in position 7. It selectively inhibits phosphodiesterase 4, leading to the relaxation of bronchial smooth muscle. Unlike Theophylline, Doxophylline has a reduced affinity for adenosine A1 and A2 receptors, which may explain its improved safety profile. It also inhibits platelet-activating factor (PAF) and reduces leukotriene production.

Dosage & Administration

• Elderly: 200 mg tablet two or three times daily.
• Adults: 400 mg tablet two or three times daily or as prescribed by the physician.
• Children:
  • Over 12 years: 10 ml syrup or 200 mg tablet two or three times daily.
  • 6-12 years: 6-9 mg/kg body weight twice daily (e.g., for a child weighing 10 kg, give 3 ml (60 mg) twice daily) or as prescribed by the physician.
    If a daily dose of 400 mg is required, the Doxophylline SR tablet should be taken once daily or as directed by the physician.

Use this medication only as directed by a registered physician.

Interaction
Ventofil should not be taken with other xanthine preparations. It is recommended to limit the consumption of caffeine-containing foods and beverages. Caution should be exercised when using Ventofil with ephedrine or other sympathomimetic drugs. The concurrent use of medications such as erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol may reduce the hepatic clearance of xanthine derivatives, leading to increased plasma drug levels. On the other hand, phenytoin, other anticonvulsants, and smoking may accelerate the clearance of xanthine derivatives, reducing their plasma half-life. In these cases, dosage adjustments may be required.

Contraindications
Ventofil is contraindicated in individuals with known hypersensitivity to Doxophylline or other xanthine derivatives. It is also contraindicated in patients with acute myocardial infarction, hypotension, and during lactation.

Side Effects
Common side effects of xanthine derivatives include nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, extrasystoles, tachypnea, and, in rare cases, hyperglycemia or albuminuria. In cases of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur. These are early signs of toxicity, and discontinuation of treatment may be necessary. After symptoms subside, treatment may be resumed at a lower dose, at the physician’s discretion.

Pregnancy & Lactation
Animal studies suggest that Doxophylline does not interfere with pre- or postnatal growth. However, due to insufficient clinical data, the use of this drug during pregnancy should be evaluated on a case-by-case basis, considering the risk-benefit ratio. Ventofil is contraindicated during lactation.

This medication does not impair alertness and does not interfere with the ability to drive or operate machinery.

Precautions & Warnings
Several factors may reduce hepatic clearance of xanthine derivatives, increasing plasma drug levels. These include age, congestive cardiac decompensation, COPD, severe liver disease, infections, and concurrent use of drugs like erythromycin, TAO, and others. In these cases, dosage adjustments may be necessary, and monitoring of blood levels is recommended.

Caution is advised when administering Ventofil to patients with cardiac disease, hypertension, elderly patients, and those with severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcers, or renal impairment. In particular, patients with congestive heart failure may experience prolonged high drug levels even after treatment is discontinued. There is no risk of addiction or dependence.

Overdose Effects
In case of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur, representing early signs of intoxication. If an overdose occurs, symptomatic treatment for cardiovascular collapse should be initiated. Since there is no specific antidote, treatment may be resumed at a lower dose after symptoms resolve, based on the physician’s discretion.

Therapeutic Class
Bronchodilator, Methyl xanthine derivatives

Storage Conditions
Store in a dry place, away from light and heat. Keep out of reach of children. Ventofil should be used only as prescribed by a specialist physician.