Veserc 16 mg

Description

Indications
Veserc is indicated for the management of Meniere’s disease and related syndromes. These conditions are often marked by episodes of vertigo, tinnitus (ringing in the ears), and/or gradual hearing loss, typically accompanied by nausea and vomiting.
Take the medication as per the advice of a registered physician.

Description
Veserc is a histamine analog developed based on the success of parenteral histamine treatments for patients with Meniere’s disease. It alleviates vertigo symptoms by improving blood circulation in the microvasculature of the inner ear. This enhanced circulation reduces pressure on the membranous labyrinth, which helps to relieve the symptoms associated with Meniere’s disease.

Pharmacology
The therapeutic effects of betahistine, the active ingredient in Veserc, are multifaceted. Meniere’s disease is believed to result from an imbalance in the fluid regulation within the ear. Betahistine primarily functions as a histamine H1-receptor agonist. By stimulating H1-receptors in the inner ear, betahistine induces vasodilation, increasing blood vessel permeability and decreasing the pressure of endolymph, thereby preventing the rupture of the labyrinth which can contribute to hearing loss. Additionally, betahistine is thought to improve the functioning of sensory vestibular organs and increase blood flow to the vestibulocochlear area, helping to alleviate vertigo.

Betahistine also acts as an H3-receptor antagonist. This action increases the release of histamine from nerve receptors, thereby boosting the H1-receptor agonist activity. The antagonism of H3-receptors increases the levels of neurotransmitters, including serotonin, in the brainstem. This helps to inhibit the activity of vestibular nuclei, improving balance and reducing vertigo symptoms.

Dosage & Administration

• Adults: The initial oral dose is between 8 to 16 mg, taken three times a day with meals. Maintenance doses typically range from 24-48 mg per day, and the daily dose should not exceed 48 mg. Dosages can be adjusted according to individual patient needs. Improvement may take several weeks of consistent use.
• Special Populations: There is limited information available on the use of betahistine in patients with liver or kidney impairments. Caution is advised in elderly patients.
• Children and Adolescents: Betahistine tablets are not recommended for children or adolescents under 18 years of age due to insufficient data on safety and efficacy.
  Take the medication as per the advice of a registered physician.

Interaction
There are no significant known interactions. However, there is a report of interaction with ethanol and compounds containing pyrimethamine and dapsone, as well as a case of increased effects when taken with salbutamol. Since Veserc is a histamine analogue, it may reduce the effectiveness of H1 antagonists when taken together.

Contraindications
Betahistine should not be used by individuals with pheochromocytoma, a tumor that can release catecholamines, leading to severe hypertension. It is also contraindicated in individuals with hypersensitivity to the active substance.

Side Effects
Veserc is generally well tolerated with no serious adverse effects reported. In rare instances, side effects such as gastrointestinal disturbances, headaches, rashes, and itching may occur.

Pregnancy & Lactation

• Pregnancy: The safety of betahistine during pregnancy has not been fully established, although animal studies show no known teratogenic effects. A careful assessment of the potential risks and benefits should be made before prescribing betahistine to pregnant women.
• Lactation: Betahistine is present in breast milk at concentrations similar to those found in plasma, although no toxicity has been reported in neonates.

Precautions & Warnings

• Caution should be exercised in patients with a history of peptic ulcers, as dyspepsia may occur.
• Betahistine should be used with care in patients with bronchial asthma, urticaria, rashes, or allergic rhinitis, as it may worsen these symptoms.
• Caution is also advised for patients with severe hypotension or those with rare hereditary conditions like galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

Effect on Ability to Drive and Use Machines
Although rare, betahistine has been associated with drowsiness in some individuals. Patients affected by drowsiness should avoid engaging in activities that require concentration, such as driving or operating machinery.

Overdose Effects
Symptoms of an overdose include nausea, vomiting, indigestion, ataxia, and seizures. Serious complications, such as convulsions or pulmonary and cardiac issues, may occur in cases of intentional overdose, especially when combined with other overdosed drugs. There is no specific antidote, but gastric lavage and symptomatic treatment are recommended.

Therapeutic Class
Drugs used in the treatment of Meniere’s disease.

Storage Conditions
Store at temperatures below 30°C, away from light and moisture. Keep out of reach of children.