Warin 5 mg

Description

Indications
Warin is used in the following conditions: Prophylaxis and/or treatment of thromboembolic complications related to atrial fibrillation and/or cardiac valve replacement. Reducing the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction. Prophylaxis and treatment of venous thrombosis and pulmonary embolism. Management of transient ischemic attacks. Consult a registered physician before using the medicine.

Description
Warin is an anticoagulant that works by inhibiting the synthesis of vitamin K-dependent clotting factors, which include Factors II, VII, IX, and X. The anticoagulant effect typically starts within 24 hours of administration and peaks in 36-48 hours, lasting for up to 48 hours after stopping the medication.

Pharmacology
Warin is a vitamin K antagonist. It inhibits the enzyme vitamin K epoxide reductase, preventing the conversion of vitamin K1 into its active form, thus blocking the synthesis of clotting factors. This results in an anticoagulated state that reduces the risk of forming harmful blood clots. The effectiveness of Warin may be influenced by several factors, including diet, other medications, and the patient’s physical condition.

Dosage & Administration

• Adults: The usual induction dose is 10 mg daily for the first 2 days. The maintenance dose typically ranges from 3 to 9 mg/day, adjusted according to the prothrombin time (INR). In emergencies, heparin and Warin may be used together initially. Regular monitoring and adjustments are necessary.
• Children: Safety and efficacy in children under 18 have not been established. Initial dosing is usually 0.1 mg/kg/day, with subsequent adjustments to maintain therapeutic INR levels. Consult a registered physician before using the medicine.

Interaction
Warfarin has a high potential for clinically significant drug interactions. It is important to consult a physician before starting or stopping any medication, including non-prescription products.

Contraindications
Warfarin should not be used in patients with active or potential hemorrhagic conditions (e.g., peptic ulcers, uncontrolled hypertension), severe hepatic or renal disease, pregnancy, known hypersensitivity to warfarin, or bacterial endocarditis. Use within 24 hours post-surgery or labor should be avoided unless deemed essential by a physician.

Side Effects
The main side effect is hemorrhage. Other side effects may include nausea, vomiting, diarrhea, hypersensitivity reactions such as rash and alopecia, skin necrosis, jaundice, and hepatic dysfunction.

Pregnancy & Lactation

• Pregnancy: Warfarin is contraindicated during pregnancy due to the risk of fetal hemorrhage.
• Lactation: Warfarin is excreted in breast milk in an inactive form. While the infant’s prothrombin times do not change, consultation with a physician is recommended for nursing mothers.

Precautions & Warnings
Regular monitoring of prothrombin time (INR) is essential. Factors such as weight loss, acute illness, and certain medications can alter the response to Warin. Emergency situations may require the administration of vitamin K or fresh-frozen plasma to reverse anticoagulation.

Overdose Effects
In the case of hemorrhage or excessive anticoagulation, Warin should be withdrawn, and treatment with vitamin K (5-10 mg) may be necessary. Fresh frozen plasma or whole blood may also be administered in severe cases.

Therapeutic Class
Anti-coagulants, Oral Anti-coagulants

Storage Conditions
Store Warin below 30°C in a dry place, away from light, and out of reach of children.