Xalcort 24 mg

Description

Indications: Xalcort is used for the treatment of various conditions, including:

• Allergic Reactions: Anaphylaxis, asthma, severe hypersensitivity reactions
• Autoimmune Disorders: Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica, systemic lupus erythematosus, and others
• Skin Conditions: Pemphigus, bullous pemphigoid, pyoderma gangrenosum
• Nephrotic Syndrome: Minimal change nephrotic syndrome, acute interstitial nephritis
• Other Conditions: Rheumatic carditis, ulcerative colitis, Crohn’s disease, uveitis, optic neuritis, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
• Cancer and Immune Suppression: Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma, and immune suppression in transplantation

Pharmacology: Xalcort contains Deflazacort, a corticosteroid that provides anti-inflammatory effects by inhibiting the enzyme Phospholipase A2, crucial for prostaglandin synthesis. Additionally, it decreases the release of certain immune system chemicals, providing immunosuppressive effects.

Dosage and Administration:

• Adults: The dose depends on the severity and condition. For acute disorders, up to 120 mg/day may be required initially. For maintenance, doses range from 3-18 mg/day.
• Children: The recommended dosage varies between 0.25-1.5 mg/kg/day depending on the condition. Gradual titration is necessary.
• Deflazacort Withdrawal: Gradual dose reduction is required after prolonged corticosteroid use to avoid relapse.

Interactions:

• Liver enzyme inducers (e.g., rifampicin, phenobarbitone) may require a dose increase.
• Liver enzyme inhibitors (e.g., ketoconazole) may allow for a dose reduction.

Contraindications:

• Hypersensitivity to Deflazacort or any components
• Live virus immunizations
• Severe infections or systemic fungal infections

Side Effects: Possible side effects include gastrointestinal disturbances, musculoskeletal issues, fluid and electrolyte disturbances, impaired healing, and hypersensitivity reactions. Rare effects include myocardial rupture, thromboembolism, and ocular issues.

Pregnancy and Lactation:

• Pregnancy: Use only if the benefits outweigh the risks, as it may cause intrauterine growth retardation.
• Lactation: Excreted in breast milk in small amounts; doses up to 50 mg/day are unlikely to harm the infant.

Precautions and Warnings:

• Caution is advised in patients with cardiac disease, hypertension, diabetes, osteoporosis, or liver/renal issues.
• Regular monitoring for side effects is recommended during long-term use.

Therapeutic Class:

• Glucocorticoids

Storage Conditions: Store below 25°C in a cool, dry place, protected from light. Keep out of children’s reach.

Please use as directed by a registered healthcare professional.