Xiclav 250 mg+62.5 mg

Description

Indications:
Xiclav is indicated for the treatment of infections caused by susceptible bacteria, including:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes
  … and other infections caused by sensitive organisms.
  Always consult a registered healthcare professional before using this medication.

Pharmacology:
Cefuroxime is a bactericidal, second-generation cephalosporin antibiotic that targets a broad spectrum of Gram-positive and Gram-negative bacteria, including many beta-lactamase-producing strains. It works by inhibiting bacterial cell wall synthesis by interfering with the transpeptidation process.

Clavulanic acid is a naturally occurring beta-lactamase inhibitor derived from Streptomyces clavuligerus. It resembles beta-lactam antibiotics in structure, binding irreversibly to beta-lactamase enzymes and rendering them inactive. This prevents the degradation of Cefuroxime by beta-lactamase enzymes, offering protection against beta-lactam-resistant bacteria.

Dosage & Administration:
Adolescents and adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg b.i.d. for 5-10 days
• Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
• Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
• Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
• Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
• Uncomplicated gonorrhoea: 1000 mg b.i.d. (single dose)
• Community-acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
• MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
• Early Lyme disease: 500 mg b.i.d. for 20 days

Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d. for 5-10 days
• Acute Otitis Media: 30 mg/kg/day b.i.d. for 10 days
• Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d. for 10 days
• Impetigo: 30 mg/kg/day b.i.d. for 10 days

Cefuroxime-clavulanic acid tablets may be taken without regard to food.
Always follow the advice of a registered healthcare professional.

Interaction:

• Co-administration of probenecid with Cefuroxime-Clavulanic Acid increases its serum concentration by 50%.
• Drugs that reduce gastric acidity may lower the bioavailability of Cefuroxime, potentially diminishing the effect of postprandial absorption.

Contraindications:
Cefuroxime-clavulanic acid is contraindicated in individuals with known allergies to cephalosporins and in patients with pseudomembranous colitis.

Side Effects:
Cefuroxime-clavulanic acid is generally well tolerated, though side effects such as nausea, vomiting, diarrhea, and abdominal discomfort may occur. Prolonged use of broad-spectrum antibiotics like Cefuroxime and Clavulanic Acid may cause overgrowth of non-susceptible microorganisms. Rarely, renal dysfunction, anaphylaxis, angioedema, pruritis, rash, and serum sickness-like urticaria may occur (<0.2%).

Pregnancy & Lactation:
Cefuroxime-clavulanic acid is safe for use during later stages of pregnancy, particularly for treating urinary and other infections. It is excreted into breast milk in small amounts; however, caution should be exercised to prevent sensitizing the infant.

Precautions & Warnings:
Cefuroxime should be used with caution in patients concurrently receiving potent diuretics or with a history of colitis.

Therapeutic Class:
Second-generation cephalosporins, vaccines, anti-sera, and immunoglobulins.

Storage Conditions:
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of reach of children.

Common Questions about Xiclav 250 mg Tablet:

• What is Xiclav 250 mg Tablet?
  Xiclav 250 mg Tablet contains Cefuroxime, a cephalosporin antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat infections caused by susceptible bacteria.

• What is Xiclav 250 mg Tablet used for?
  It is used to treat infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, skin infections, urinary tract infections, gonorrhoea, pneumonia, typhoid fever, and Lyme disease.

• How long does it take for Xiclav 250 mg Tablet to take effect?
  It typically starts working within 2-3 hours after taking it.

• How long do the effects of this medicine last?
  The effects last for an average of 4-8 hours.

• Is it safe to consume alcohol while taking this medicine?
  Interaction with alcohol is unknown. It is recommended to consult your doctor before consuming alcohol.

• Is Xiclav 250 mg Tablet habit-forming?
  No, it is not habit-forming.

• Can this medicine be taken during pregnancy?
  Xiclav 250 mg Tablet is considered safe to use during pregnancy to treat bacterial infections, but consult your doctor before use.

• Can Xiclav 250 mg Tablet be taken while breastfeeding?
  Yes, it is safe during breastfeeding, as it is excreted into breast milk in small quantities.

Quick Tips:

• Complete the full course of treatment, even if you feel better, to prevent the infection from returning or becoming harder to treat.
• Take with food to avoid an upset stomach.
• If you experience diarrhea, consider taking probiotics. Seek medical advice if you have bloody stools or abdominal cramps.
• If you develop an itchy rash, swelling of the face, throat, or difficulty breathing, stop taking the medicine and inform your doctor immediately.
• Never use leftover medicine for future infections. Always consult your doctor before using antibiotics.

Always follow the guidance of a registered healthcare professional.