Xyflo 5 mg

Description

Indications Xyflo is prescribed for:

• Long-term management and prevention of asthma symptoms.
• Prevention of Exercise-Induced Bronchoconstriction (EIB).
• Relief from symptoms of Seasonal and Perennial Allergic Rhinitis.

(Use this medication as directed by a registered physician.)

Pharmacology Montelukast is a selective leukotriene receptor antagonist that works by inhibiting the cysteinyl leukotriene receptor (CysLT1). Cysteinyl leukotrienes (LTC4, LTD4, LTE4) are derived from arachidonic acid metabolism and are released by cells such as mast cells and eosinophils. These leukotrienes contribute to airway inflammation, bronchoconstriction, and tissue swelling, leading to asthma and allergic rhinitis symptoms. By blocking these receptors, Montelukast helps reduce inflammation and improve breathing.

Dosage & Administration

• Adults and adolescents (15 years and older) with asthma or allergic rhinitis: 10 mg once daily.
• Children (6 to 14 years): 5 mg once daily.
• Children (2 to 5 years): 4 mg once daily.
• Infants and toddlers (6 months to 5 years): 4 mg oral granules once daily, administered directly or mixed with a spoonful of cold water or soft food.

Special Population Considerations:

• Pediatric Use: Proven safe and effective for children aged 6 months to 14 years.
• Hepatic Insufficiency: No dosage adjustment required for mild-to-moderate liver impairment.
• Renal Insufficiency: No dose modification necessary.
• Elderly Patients: No dosage adjustment needed, though the plasma half-life may be slightly prolonged.

(Use this medication as directed by a registered physician.)

Drug Interactions Xyflo has been safely used with various medications for asthma management. No significant interactions have been observed with drugs such as theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, and warfarin. However, caution is advised when used with phenobarbital or rifampin, as they may reduce Montelukast’s effectiveness by increasing metabolism.

Contraindications Xyflo should not be used in patients with known hypersensitivity to Montelukast or any of its ingredients.

Side Effects

• Common: Headache, nausea, vomiting, diarrhea, fever, skin reactions, upper respiratory infections, and stomach discomfort.
• Uncommon: Drowsiness, dizziness, irritability, anxiety, sleep disturbances, muscle pain, dry mouth, and abnormal behavior.
• Rare: Angioedema, hallucinations, memory loss, hepatic disorders, palpitations, pulmonary eosinophilia, and suicidal tendencies.

Pregnancy & Lactation Montelukast crosses the placenta in animal studies, but adequate human studies are lacking. It should only be used in pregnancy if necessary. Since many drugs pass into breast milk, caution should be exercised when prescribing Montelukast to breastfeeding mothers.

Precautions & Warnings

• Xyflo is not a rescue medication for acute asthma attacks and should not replace inhaled corticosteroids abruptly.
• Patients with aspirin sensitivity should continue avoiding aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) while taking Xyflo.
• Regular monitoring is advised if used alongside hepatic enzyme-inducing drugs like phenobarbital.

Overdose Effects Most cases of overdose do not result in severe symptoms. Reported effects include abdominal pain, drowsiness, vomiting, headache, increased thirst, and hyperactivity. If overdose occurs, general supportive measures should be taken, such as gastric lavage and clinical monitoring.

Therapeutic Class Leukotriene Receptor Antagonists

Storage Conditions Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Common Questions

• What is Xyflo used for? Xyflo is used to manage asthma and allergic rhinitis by reducing inflammation and keeping airways open.
• How long does it take for Xyflo to work? Effects can be observed within 1-3 hours of administration, but it must be taken regularly for optimal benefits.
• Does Xyflo need to be taken with food? It can be taken with or without food as directed by your physician.
• What should I do if I miss a dose? Take the missed dose as soon as possible. If it is close to the next dose, skip the missed dose—do not double up.
• Can Xyflo be used during pregnancy? It should be avoided unless clearly necessary and prescribed by a doctor.

General Instructions

• Take Xyflo as prescribed and do not change the dosage without consulting your doctor.
• Continue using Xyflo even if you feel better, as it helps prevent asthma and allergy symptoms.
• Xyflo is not a substitute for fast-acting inhalers. Seek immediate medical help for sudden breathing problems.
• Avoid triggers that worsen asthma or allergic reactions.
• Consult your doctor before using Xyflo if you are pregnant or breastfeeding.