Zeltas

Description

Indications

Zeltas Nasal Spray is indicated for the relief of symptoms associated with seasonal allergic rhinitis in patients 6 years and older who require a combination of Azelastine Hydrochloride (antihistamine) and Fluticasone Propionate (corticosteroid) for effective symptom control.

Note: Use this medication only as directed by a registered physician.

Pharmacology

• Azelastine Hydrochloride: A histamine H1-receptor antagonist that helps reduce allergy symptoms by blocking histamine receptors. Its metabolite, desmethylazelastine, also has anti-allergic properties.
• Fluticasone Propionate: A synthetic corticosteroid with potent anti-inflammatory effects. It reduces allergic inflammation by acting on multiple immune cells (mast cells, eosinophils, neutrophils, lymphocytes) and inflammatory mediators (histamine, leukotrienes, cytokines).

Dosage and Administration

Adults and Children (6 years and older):

• One spray in each nostril twice daily.

Children below 6 years:

• Safety and effectiveness have not been established for this age group.

Note: Use under medical supervision.

How to Use Zeltas Nasal Spray

1. Shake the bottle gently and remove the dust cover.
2. Prime the spray by pressing down several times until a fine mist appears.
3. Gently blow your nose to clear the nostrils.
4. Close one nostril and insert the applicator into the other nostril.
5. Tilt your head slightly forward and press down the applicator while inhaling through your nose.
6. Breathe out through your mouth.
7. Repeat for the other nostril if needed.

Cleaning Instructions

• Clean the nasal applicator once a week by washing it with warm water.
• Let it air dry before reassembling.

Contraindications

No known contraindications.

Side Effects

Common side effects (more than 2 percent incidence) include:

• Dysgeusia (altered taste)
• Epistaxis (nosebleed)
• Headache

Use in Pregnancy and Lactation

• Pregnancy Category C: Should only be used if the benefits outweigh the risks.
• Lactation: Unknown if the drug passes into breast milk. Use with caution.

Precautions and Warnings

• Avoid activities that require mental alertness, such as driving or operating machinery, due to potential drowsiness.
• Do not use with alcohol or central nervous system depressants as they may intensify drowsiness.
• Prolonged use may lead to hypercorticism (excess steroid effects).

Overdose Effects

• Azelastine Hydrochloride: May cause excessive drowsiness in case of overdose.
• Fluticasone Propionate: Chronic overuse may lead to hypercorticism and adrenal suppression.

Therapeutic Class

Nasal Steroid Preparations

Storage Instructions

• Store below 25°C, away from direct light.
• Do not refrigerate.
• Keep out of reach of children.