Zeropain 10 mg

Description

Indications:
Zeropain is indicated for short-term management of moderate to severe acute post-operative pain. Zeropain ophthalmic solution is used to relieve pain, inflammation, and light sensitivity after ocular surgery and may also reduce eye inflammation or redness from seasonal allergies.
Use as directed by a registered physician.

Description:
Zeropain belongs to the pyrrolo-pyrrole group of NSAIDs. It inhibits prostaglandin synthesis and acts as a peripherally acting analgesic. It is highly protein-bound, metabolized primarily in the liver, and excreted through the urine.

Pharmacology:
Ketorolac Tromethamine is a potent NSAID analgesic that inhibits the cyclooxygenase enzyme system, reducing prostaglandin synthesis. At its analgesic dose, it demonstrates minimal anti-inflammatory effects.

Dosage & Administration:

• Tablet: 10 mg every 4-6 hours (maximum 40 mg/day). Recommended for short-term use (up to 7 days).
• Injection (Single Dose):
  • IM (Adults <65 years): 60 mg.
  • IM (Adults >65 years, renally impaired, or <50 kg): 30 mg.
  • IV (Adults <65 years): 30 mg.
  • IV (Adults >65 years, renally impaired, or <50 kg): 15 mg.
  • IM (2-16 years): 1 mg/kg (max 30 mg).
  • IV (2-16 years): 0.5 mg/kg (max 15 mg).
• Injection (Multiple Dose):
  • Adults <65 years: 30 mg every 6 hours (max 120 mg/day).
  • Adults >65 years, renally impaired, or <50 kg: 15 mg every 6 hours (max 60 mg/day).
• Eye Drops: 1 drop in each eye, 4 times daily.

Drug Interactions:

• NSAIDs or aspirin: May increase side effects.
• Anti-coagulants: Enhance the anti-coagulant effect.
• Beta blockers: Reduce anti-hypertensive effects.
• ACE inhibitors: Increase risk of renal impairment.
• Methotrexate: May increase methotrexate toxicity.

Contraindications:
Ketorolac is contraindicated in patients with hypersensitivity to NSAIDs, children under 16, and as a prophylactic analgesic before surgery.

Side Effects:
Common side effects include nausea, vomiting, gastrointestinal bleeding, peptic ulcer, headache, drowsiness, bradycardia, hypertension, chest pain, fatigue, pulmonary edema, and female infertility.

Pregnancy & Lactation:
Ketorolac is categorized as pregnancy category C by the FDA. It should be avoided during pregnancy and lactation unless the potential benefits outweigh the risks.

Precautions & Warnings:

• Use with caution in patients over 65 years, those with suspected peptic ulcers, gastrointestinal bleeding, asthma, or liver dysfunction.
• Eye Drops: Discontinue immediately if corneal epithelial breakdown occurs and avoid use while wearing contact lenses.

Therapeutic Class:
Drugs for Rheumatoid Arthritis and Non-Opioid Analgesics.

Storage:
Store in a dry place away from light and heat. Keep out of reach of children.