Zervin 0.24%

Description

Indications
Zervin 0.24% ophthalmic solution is indicated for the treatment of ocular itching associated with allergic conjunctivitis.

Pharmacology
Cetirizine is an antihistamine that works as a histamine-1 (H1) receptor antagonist. Its effects are mediated through the selective inhibition of H1 histamine receptors. Cetirizine has shown negligible anticholinergic and antiserotonergic activity in animal models. In vitro receptor binding studies reveal no significant affinity for receptors other than H1. In healthy subjects, one drop of cetirizine ophthalmic solution 0.24% results in a mean plasma Cmax of 1.7 ng/mL after a single dose and 3.1 ng/mL after twice-daily dosing for one week. The mean terminal half-life of cetirizine is 8.6 hours after a single dose and 8.2 hours after twice-daily dosing for one week.

Dosage & Administration
Adults and children (age 2 years and above): Instill one drop in the affected eye(s) twice daily, approximately 8 hours apart.

Side Effects
The most common side effects include ocular hyperemia, instillation site pain, and reduction in visual acuity.

Pregnancy & Lactation
Pregnancy: There are no well-controlled studies in pregnant women. Zervin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is unknown if cetirizine is excreted in breast milk. The developmental benefits of breastfeeding should be considered along with the mother’s need for the drug and any potential effects on the breastfed infant.

Precautions & Warnings
Do not touch the dropper tip to the eyelids or surrounding areas to prevent contamination. Keep the bottle closed when not in use. Avoid wearing contact lenses if the eye is red. Remove contact lenses prior to administration and wait 10 minutes before reinserting.

Use in Special Populations
Pediatric Use: Safety and effectiveness have been established for children 2 years of age and older. Geriatric Use: No significant differences in safety or effectiveness between elderly and younger patients have been observed.

Therapeutic Class
Ophthalmic Anti-allergic preparations

Storage Conditions
Store below 30°C, protect from light. Do not freeze. Use within 4 weeks after opening. Keep out of reach of children.