Zithrin 500 mg

Description

Indications:
Zithrin is an effective antibiotic used to treat a variety of infections caused by susceptible bacteria. It is indicated for:

• Lower respiratory tract infections, including bronchitis and pneumonia
• Upper respiratory tract infections such as sinusitis and pharyngitis/tonsillitis
• Otitis media
• Skin and soft tissue infections
• Non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis

Dosage & Administration:

• Adults: 500 mg once daily for 3 days or 500 mg on day 1, followed by 250 mg once daily for the next 4 days.
• Children: 10 mg/kg once daily for 3 days (dosing adjustments based on body weight).
• Sexually transmitted infections: 1 g as a single dose or as per your doctor’s recommendation.
• IV Therapy: For community-acquired pneumonia, 500 mg daily for at least 2 days, followed by oral therapy.

Always follow your healthcare provider’s advice for dosage and duration.

Pharmacology:
Azithromycin is acid-stable and rapidly absorbed. It concentrates at the infection site due to its high lipid solubility and extended half-life, allowing for convenient once-daily dosing. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively treating gram-positive, gram-negative, and atypical bacteria.

Contraindications:

• Hypersensitivity to azithromycin or other macrolides
• Co-administration with ergot derivatives is contraindicated
• Not recommended in patients with severe hepatic disease

Common Side Effects:

• Gastrointestinal issues: nausea, vomiting, abdominal pain, diarrhea
• Allergic reactions: skin rash or photosensitivity
• Rare: transient hearing impairment and liver enzyme elevation

Pregnancy & Lactation:

• Pregnancy Category B: No evidence of harm in animal studies, but limited human data. Use only if no safer alternatives are available.
• Caution is advised if administered to breastfeeding mothers.

Drug Interactions:

• Take azithromycin at least 1 hour before or 2 hours after antacids.
• Monitor digoxin, warfarin, and cyclosporin levels if used concurrently.
• Avoid co-administration with ergot derivatives due to the risk of ergotism.

Storage Conditions:
Store in a cool, dry place away from light and heat. Keep out of reach of children.