Zolium 0.25 mg

Description

Indications Zolium is prescribed for the management of:

• Anxiety disorders
• Short-term relief of anxiety symptoms
• Anxiety associated with depressive conditions
• Panic disorder, with or without agoraphobia

Use this medication only as directed by a registered physician.

Pharmacology Alprazolam belongs to the triazole subclass of 1,4-benzodiazepines. It acts as an anxiolytic with sedative and anticonvulsant properties. The therapeutic effects of Alprazolam are believed to be mediated through its interaction with the Gamma-Aminobutyric Acid (GABA)-benzodiazepine receptor complex. Similar to other benzodiazepines, its central nervous system depressant effects range from mild cognitive impairment to pronounced sedation, depending on the dosage.

Dosage & Administration

• The initial recommended dose is 0.25 to 0.5 mg taken three times daily.
• Based on patient response, the dose may be increased at 3 to 4-day intervals, with increments not exceeding 1 mg per day.
• The maximum dosage should not surpass 4 mg per day.
• In some cases of panic disorder, doses up to 10 mg per day may be necessary, requiring periodic reassessment and possible dosage adjustment.
• The dosage should always be tailored to achieve the desired effect using the lowest effective dose. If adverse effects occur at the starting dose, a dose reduction may be necessary.
• Discontinuation should be gradual, with dose reductions not exceeding 0.5 mg every three days to minimize withdrawal symptoms.

Special Populations:

• Elderly patients and those with severe liver disease: The initial dose is 0.25 mg, taken two to three times daily, with gradual increments if well tolerated.
• Alprazolam 1 mg formulation: Patients switching from multiple doses of Alprazolam 0.25 mg or 0.5 mg can take a single daily dose in the morning. The tablets should be swallowed whole and not crushed, chewed, or broken.

Use this medication only as directed by a registered physician.

Drug Interactions The sedative effects of Zolium may be intensified when combined with other central nervous system depressants, including:

• Psychotropic medications
• Anticonvulsants
• Antihistamines
• Alcohol
• Oral contraceptives

Side Effects Side effects are more common at the beginning of treatment and typically diminish with continued use. The most frequently reported side effects include:

• Drowsiness
• Lightheadedness
• Depression
• Headache
• Confusion
• Dry mouth
• Constipation

Pregnancy & Lactation

• Alprazolam is classified under pregnancy category D, meaning it should be avoided during pregnancy due to potential risks.
• It is presumed to be excreted in breast milk; therefore, breastfeeding is not recommended for mothers using Alprazolam.

Precautions & Warnings

• Zolium may cause psychological and physical dependence. Dosage adjustments or abrupt discontinuation should only be done under medical supervision.
• The duration of therapy should be determined by a physician.
• Caution is advised when prescribing Zolium to patients with hepatic or renal impairment, chronic respiratory conditions, or sleep apnea.

Use in Special Populations

• The safety and efficacy of Zolium in individuals below 18 years of age have not been established.

Overdose Effects Symptoms of overdose may include:

• Excessive drowsiness
• Confusion
• Impaired coordination
• Reduced reflexes
• Coma

In cases of overdose, immediate medical intervention is required, including gastric lavage and supportive care.

Therapeutic Class Benzodiazepine Sedatives

Storage Conditions

• Store below 30°C in a dry place, away from direct light and moisture.
• Keep out of reach of children.