DESOTOP 15 GM

Description

Indications

Desotop Gel is indicated for the treatment of mild to moderate atopic dermatitis in patients aged 3 months and older.
Consult a registered physician before use.

Pharmacology

Desotop Gel contains Desonide, a synthetic nonfluorinated corticosteroid designed for topical dermatologic application. Its primary properties include anti-inflammatory, antipruritic, and vasoconstrictive effects.

• Mechanism of Action:
  Desonide inhibits phospholipase A2 through the induction of proteins called lipocortins, which regulate the production of inflammatory mediators like prostaglandins and leukotrienes. These mediators originate from arachidonic acid, which is released from membrane phospholipids via phospholipase A2.

• Absorption and Metabolism:
  Once absorbed through the skin, Desonide undergoes pharmacokinetic pathways similar to systemically administered corticosteroids.

Dosage & Administration

• Application: Apply a thin layer of Desotop Gel to the affected area twice daily and rub in gently.

• Duration: Therapy should be discontinued once adequate control is achieved. If there is no improvement within 4 weeks, discontinue use.

• Pediatric Use: Desotop Gel is not recommended for patients under 3 months of age, as safety and effectiveness have not been established.

For external use only. Avoid contact with eyes.

Contraindications

Desotop Gel is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

The most common local side effects include:

• Burning sensation, rash, and pruritus at the application site.

Other side effects, which may occur less frequently (especially with occlusive dressings or higher-potency corticosteroids), include:

• Folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.

Pregnancy & Lactation

• Pregnancy:
  Desotop Gel is classified as Pregnancy Category C. There are no adequate studies in pregnant women, so it should only be used if the potential benefit outweighs the risks to the fetus.

• Lactation:
  While systemically administered corticosteroids can appear in breast milk, the extent of absorption and systemic effects from topical Desonide is unknown. Caution is advised when administering Desotop Gel to nursing mothers.

Precautions & Warnings

• External Use Only: Avoid contact with the eyes and do not apply to underarm or groin areas in pediatric patients.

• Irritation: Discontinue use if irritation occurs and seek appropriate treatment.

• Systemic Effects: Prolonged or excessive use may lead to reversible HPA axis suppression or glucocorticosteroid insufficiency upon withdrawal.

• Infection Control: If the condition does not improve or worsens, discontinue use until infection is controlled.

Overdose Effects

Excessive application or prolonged use may result in systemic corticosteroid effects, including HPA axis suppression.

Therapeutic Class

Other Topical Corticosteroids.

Storage Conditions

• Store below 30°C, protected from light and moisture.

• Keep out of reach of children.