Xiclav 500 mg+125 mg

Description

Xiclav 500 mg Tablet

Indications
Xiclav 500 mg Tablet is prescribed for the treatment of infections caused by susceptible bacteria, including:

• Pharyngitis/Tonsillitis due to Streptococcus pyogenes.
• Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes.
• Sinusitis, bronchitis, skin and soft tissue infections (SSTI), urinary tract infections (UTI), gonorrhea, pneumonia, typhoid fever, and other bacterial infections as determined by a healthcare professional.

Pharmacology
Xiclav contains two active ingredients:

• Cefuroxime: A second-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is effective against both Gram-positive and Gram-negative bacteria, including many beta-lactamase-producing strains.
• Clavulanic Acid: A beta-lactamase inhibitor derived from Streptomyces clavuligerus. It prevents the degradation of cefuroxime by beta-lactamase enzymes, thereby enhancing its efficacy against resistant bacterial strains.

Dosage & Administration
For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days
• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days
• Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days
• Uncomplicated skin and soft tissue infections: 250-500 mg twice daily for 10 days
• Uncomplicated urinary tract infections: 250 mg twice daily for 7-10 days
• Uncomplicated gonorrhea: 1000 mg as a single dose
• Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days
• Multi-drug resistant (MDR) typhoid fever: 500 mg twice daily for 10-14 days
• Early Lyme disease: 500 mg twice daily for 20 days

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days
• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days
• Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days
• Impetigo: 30 mg/kg/day in two divided doses for 10 days

The tablet can be taken with or without food.

Drug Interactions

• Co-administration with probenecid increases cefuroxime levels in the blood.
• Medications that reduce gastric acidity may lower cefuroxime’s bioavailability and affect absorption.

Contraindications

• Patients with known allergy to cephalosporin antibiotics.
• Patients with a history of pseudomembranous colitis.

Side Effects
Xiclav is generally well-tolerated, but some patients may experience:

• Nausea, vomiting, diarrhea, and abdominal discomfort.
• Rare cases of renal dysfunction, allergic reactions (e.g., anaphylaxis, angioedema, rash), and serum sickness-like urticaria.
• Prolonged use may lead to the overgrowth of non-susceptible microorganisms.

Pregnancy & Lactation

• While antibiotics should ideally be avoided in the first trimester, Xiclav can be used in later pregnancy to treat bacterial infections.
• Small amounts of cefuroxime and clavulanic acid are excreted in breast milk, so caution should be exercised when administered to breastfeeding mothers.

Precautions & Warnings

• Use with caution in patients taking potent diuretics.
• Patients with a history of colitis should take this medication under medical supervision.

Therapeutic Class
Second-generation cephalosporins, vaccines, antisera, and immunoglobulins.

Storage Conditions
Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.

Frequently Asked Questions
What is Xiclav 500 mg Tablet used for?
It is used to treat bacterial infections such as pharyngitis, tonsillitis, sinusitis, bronchitis, skin infections, urinary tract infections, pneumonia, and typhoid fever.

How quickly does Xiclav 500 mg Tablet work?
It starts acting within 2-3 hours after administration.

How long do the effects last?
The effects typically last for 4-8 hours.

Is alcohol consumption safe while taking this medication?
There is no confirmed interaction, but it is advisable to consult a doctor before consuming alcohol.

Is Xiclav 500 mg Tablet habit-forming?
No habit-forming tendencies have been reported.

Can this medication be used during pregnancy?
Yes, but it should be taken only under medical supervision.

Can Xiclav 500 mg Tablet be used while breastfeeding?
Yes, it is safe for use during breastfeeding as it passes into breast milk in minimal amounts.

Quick Tips

• Complete the full course of treatment even if symptoms improve early.
• Take with food to minimize stomach discomfort.
• If diarrhea occurs, consider taking probiotics and inform your doctor if symptoms persist.
• Stop use immediately and seek medical attention if you experience allergic reactions such as rashes, swelling, or breathing difficulties.
• Do not use leftover medication for future infections. Always consult your doctor before taking antibiotics.